Gene description for Pf4
Gene name	platelet factor 4
Gene symbol	Pf4
Other names/aliases	Cxcl4 PF-4 Pf4a RATPF4A
Species	Rattus norvegicus
Database cross references - Pf4
ExoCarta	ExoCarta_360918
Vesiclepedia	VP_360918
Entrez Gene	360918
UniProt	P06765
Pf4 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Pf4

Molecular Function     chemokine activity GO:0008009 IBA     chemokine activity GO:0008009 ISO     heparin binding GO:0008201 ISO     heparin binding GO:0008201 ISS     CXCR chemokine receptor binding GO:0045236 IBA     receptor ligand activity GO:0048018 ISO     CXCR3 chemokine receptor binding GO:0048248 ISO     CXCR3 chemokine receptor binding GO:0048248 ISS Biological Process     monocyte chemotaxis GO:0002548 ISO     inflammatory response GO:0006954 IBA     immune response GO:0006955 IDA     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISO     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISS     positive regulation of gene expression GO:0010628 ISO     positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO     negative regulation of angiogenesis GO:0016525 ISO     negative regulation of angiogenesis GO:0016525 ISS     cytokine-mediated signaling pathway GO:0019221 ISO     cytokine-mediated signaling pathway GO:0019221 ISS     platelet activation GO:0030168 ISO     platelet activation GO:0030168 ISS     negative regulation of blood coagulation GO:0030195 ISO     osteoclast differentiation GO:0030316 HEP     neutrophil chemotaxis GO:0030593 IBA     leukocyte chemotaxis GO:0030595 ISO     leukocyte chemotaxis GO:0030595 ISS     positive regulation of tumor necrosis factor production GO:0032760 ISO     regulation of cell population proliferation GO:0042127 ISO     regulation of cell population proliferation GO:0042127 ISS     defense response to protozoan GO:0042832 ISO     negative regulation of MHC class II biosynthetic process GO:0045347 ISO     positive regulation of macrophage differentiation GO:0045651 ISO     negative regulation of megakaryocyte differentiation GO:0045653 ISO     negative regulation of megakaryocyte differentiation GO:0045653 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     negative regulation of inflammatory response GO:0050728 IDA     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA     antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 ISO     protein-containing complex assembly GO:0065003 IPI     cellular response to lipopolysaccharide GO:0071222 IBA     response to aldosterone GO:1904044 IEP     negative regulation of T-helper 17 cell differentiation GO:2000320 IDA     negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 ISO Subcellular Localization     extracellular space GO:0005615 IBA     extracellular space GO:0005615 ISO     cytoplasm GO:0005737 ISO     platelet alpha granule GO:0031091 IDA     vesicle GO:0031982 IDA     protein-containing complex GO:0032991 IDA