Gene description for Pf4
Gene name	platelet factor 4
Gene symbol	Pf4
Other names/aliases	Cxcl4 PF-4 Pf4a RATPF4A
Species	Rattus norvegicus
Database cross references - Pf4
ExoCarta	ExoCarta_360918
Entrez Gene	360918
UniProt	P06765
Pf4 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046

Gene ontology annotations for Pf4

Molecular Function     molecular_function GO:0003674 ND     CXCR3 chemokine receptor binding GO:0048248 ISS     heparin binding GO:0008201 ISS     CXCR chemokine receptor binding GO:0045236 IBA     chemokine activity GO:0008009 IBA Biological Process     positive regulation of macrophage differentiation GO:0045651 ISO     negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 ISO     chemokine-mediated signaling pathway GO:0070098 IBA     protein complex assembly GO:0006461 IPI     G-protein coupled receptor signaling pathway GO:0007186 IBA     inflammatory response GO:0006954 IBA     negative regulation of MHC class II biosynthetic process GO:0045347 ISO     response to lipopolysaccharide GO:0032496 IBA     positive regulation of leukocyte chemotaxis GO:0002690 IBA     positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO     positive regulation of cAMP metabolic process GO:0030816 ISS     cytokine-mediated signaling pathway GO:0019221 ISS     positive regulation of gene expression GO:0010628 ISO     negative regulation of angiogenesis GO:0016525 ISS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS     positive regulation of cAMP-mediated signaling GO:0043950 ISS     leukocyte chemotaxis GO:0030595 ISS     regulation of cell proliferation GO:0042127 ISS     negative regulation of cytolysis GO:0045918 ISO     platelet activation GO:0030168 ISS     positive regulation of tumor necrosis factor production GO:0032760 ISO     negative regulation of megakaryocyte differentiation GO:0045653 ISS     immune response GO:0006955 IDA Subcellular Localization     vesicle GO:0031982 IDA     platelet alpha granule GO:0031091 IDA     extracellular space GO:0005615 IBA     protein complex GO:0043234 IDA