Gene description for Piezo1
Gene name piezo-type mechanosensitive ion channel component 1
Gene symbol Piezo1
Other names/aliases Fam38a
Mib
Species Rattus norvegicus
 Database cross references - Piezo1
ExoCarta ExoCarta_361430
Vesiclepedia VP_361430
Entrez Gene 361430
UniProt Q0KL00  
 Piezo1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Piezo1
Molecular Function
    monoatomic cation channel activity GO:0005261 IBA
    monoatomic cation channel activity GO:0005261 ISO
    monoatomic cation channel activity GO:0005261 ISS
    mechanosensitive monoatomic ion channel activity GO:0008381 IBA
    mechanosensitive monoatomic ion channel activity GO:0008381 IEA
    mechanosensitive monoatomic ion channel activity GO:0008381 ISO
    mechanosensitive monoatomic ion channel activity GO:0008381 ISS
    identical protein binding GO:0042802 ISO
    mechanosensitive monoatomic cation channel activity GO:0140135 IEA
    mechanosensitive monoatomic cation channel activity GO:0140135 ISO
Biological Process
    monoatomic cation transport GO:0006812 ISO
    monoatomic cation transport GO:0006812 ISO
    monoatomic cation transport GO:0006812 ISS
    positive regulation of myotube differentiation GO:0010831 IEA
    positive regulation of myotube differentiation GO:0010831 ISO
    positive regulation of myotube differentiation GO:0010831 ISS
    positive regulation of integrin activation GO:0033625 IEA
    positive regulation of integrin activation GO:0033625 ISO
    positive regulation of integrin activation GO:0033625 ISS
    positive regulation of cell-cell adhesion mediated by integrin GO:0033634 IEA
    positive regulation of cell-cell adhesion mediated by integrin GO:0033634 ISO
    positive regulation of cell-cell adhesion mediated by integrin GO:0033634 ISS
    monoatomic ion transmembrane transport GO:0034220 IEA
    regulation of membrane potential GO:0042391 IBA
    regulation of membrane potential GO:0042391 ISO
    detection of mechanical stimulus GO:0050982 IBA
    detection of mechanical stimulus GO:0050982 ISO
    cellular response to mechanical stimulus GO:0071260 IBA
    monoatomic cation transmembrane transport GO:0098655 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    lamellipodium membrane GO:0031258 IEA
    stereocilium GO:0032420 ISO
    stereocilium GO:0032420 ISS
    cuticular plate GO:0032437 ISO
    cuticular plate GO:0032437 ISS
    endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 IEA
 Experiment description of studies that identified Piezo1 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Piezo1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Piezo1 is involved
No pathways found





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