Gene description for Iqgap1
Gene name IQ motif containing GTPase activating protein 1
Gene symbol Iqgap1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Iqgap1
ExoCarta ExoCarta_361598
Vesiclepedia VP_361598
Entrez Gene 361598
 Iqgap1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Iqgap1
Molecular Function
    MAP-kinase scaffold activity GO:0005078 ISO
    GTPase activator activity GO:0005096 IBA
    calcium ion binding GO:0005509 ISO
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 ISO
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 ISO
    protein kinase binding GO:0019901 ISO
    protein phosphatase binding GO:0019903 ISO
    protein domain specific binding GO:0019904 ISO
    small GTPase binding GO:0031267 ISO
    protein serine/threonine kinase activator activity GO:0043539 ISO
    S100 protein binding GO:0044548 ISO
    protein-containing complex binding GO:0044877 IPI
    actin filament binding GO:0051015 IBA
    mitogen-activated protein kinase binding GO:0051019 IPI
    molecular adaptor activity GO:0060090 ISO
Biological Process
    MAPK cascade GO:0000165 IEA
    regulation of cytokine production GO:0001817 ISO
    epidermal growth factor receptor signaling pathway GO:0007173 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 ISO
    regulation of mitotic cell cycle GO:0007346 ISO
    fibroblast growth factor receptor signaling pathway GO:0008543 ISO
    fibroblast migration GO:0010761 IBA
    fibroblast migration GO:0010761 ISO
    cell migration GO:0016477 ISO
    negative regulation of dephosphorylation GO:0035305 ISO
    cellular response to platelet-derived growth factor stimulus GO:0036120 ISO
    positive regulation of MAP kinase activity GO:0043406 IMP
    positive regulation of MAPK cascade GO:0043410 ISO
    cellular response to fibroblast growth factor stimulus GO:0044344 ISO
    positive regulation of protein kinase activity GO:0045860 ISO
    platelet-derived growth factor receptor signaling pathway GO:0048008 ISO
    positive regulation of focal adhesion assembly GO:0051894 IMP
    caveola assembly GO:0070836 IEA
    caveola assembly GO:0070836 ISO
    cellular response to calcium ion GO:0071277 ISO
    cellular response to epidermal growth factor stimulus GO:0071364 ISO
    regulation of postsynapse assembly GO:0150052 IDA
    regulation of postsynapse assembly GO:0150052 IMP
    positive regulation of dendrite development GO:1900006 IMP
    positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 IMP
    mitotic actomyosin contractile ring assembly actin filament organization GO:1903479 IBA
    positive regulation of protein localization GO:1903829 IMP
    positive regulation of vascular associated smooth muscle cell migration GO:1904754 IMP
    neuron projection extension GO:1990138 ISO
    response to angiotensin GO:1990776 IEP
Subcellular Localization
    ruffle GO:0001726 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    microtubule GO:0005874 ISO
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 ISO
    focal adhesion GO:0005925 IDA
    focal adhesion GO:0005925 ISO
    cell cortex GO:0005938 IBA
    cytoplasmic side of plasma membrane GO:0009898 ISO
    actin cytoskeleton GO:0015629 IDA
    microtubule cytoskeleton GO:0015630 IDA
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 ISO
    lateral plasma membrane GO:0016328 ISO
    axon GO:0030424 IDA
    growth cone GO:0030426 IDA
    midbody GO:0030496 ISO
    cortical actin cytoskeleton GO:0030864 ISO
    cell leading edge GO:0031252 ISO
    protein-containing complex GO:0032991 IDA
    cytoplasmic ribonucleoprotein granule GO:0036464 ISO
    neuron projection GO:0043005 IDA
    neuron projection GO:0043005 ISO
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IMP
    ribonucleoprotein complex GO:1990904 ISO
 Experiment description of studies that identified Iqgap1 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Iqgap1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Iqgap1 is involved
No pathways found





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