Gene description for Iqgap1
Gene name IQ motif containing GTPase activating protein 1
Gene symbol Iqgap1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Iqgap1
ExoCarta ExoCarta_361598
Entrez Gene 361598
 Iqgap1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Iqgap1
Molecular Function
    protein complex binding GO:0032403 IPI
    calmodulin binding GO:0005516 ISO
    GTPase activator activity GO:0005096 IEA
    protein kinase binding GO:0019901 ISO
    protein phosphatase binding GO:0019903 ISO
    protein serine/threonine kinase activator activity GO:0043539 ISO
    protein binding GO:0005515 IPI
    Rac GTPase binding GO:0048365 ISO
    Rho GTPase binding GO:0017048 ISO
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 ISO
Biological Process
    epidermal growth factor receptor signaling pathway GO:0007173 ISO
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISO
    fibroblast growth factor receptor signaling pathway GO:0008543 ISO
    positive regulation of GTPase activity GO:0043547 IEA
    cellular response to calcium ion GO:0071277 ISO
    regulation of cytokine production GO:0001817 ISO
    positive regulation of protein kinase activity GO:0045860 ISO
    negative regulation of dephosphorylation GO:0035305 ISO
    platelet-derived growth factor receptor signaling pathway GO:0048008 ISO
    cellular response to epidermal growth factor stimulus GO:0071364 ISO
    cellular response to platelet-derived growth factor stimulus GO:0036120 ISO
    small GTPase mediated signal transduction GO:0007264 IEA
    neuron projection extension GO:1990138 ISO
    cellular response to fibroblast growth factor stimulus GO:0044344 ISO
Subcellular Localization
    focal adhesion GO:0005925 ISO
    nucleoplasm GO:0005654 ISO
    microtubule GO:0005874 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasmic ribonucleoprotein granule GO:0036464 ISO
    cell leading edge GO:0031252 ISO
    midbody GO:0030496 ISO
    growth cone GO:0030426 IDA
    microtubule cytoskeleton GO:0015630 IDA
    ribonucleoprotein complex GO:0030529 ISO
    protein complex GO:0043234 IDA
    axon GO:0030424 IDA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 ISO
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
    cytoplasm GO:0005737 ISO
    cell-cell junction GO:0005911 ISO
    lateral plasma membrane GO:0016328 ISO
    actin cytoskeleton GO:0015629 IDA
    cell junction GO:0030054 ISO
    neuron projection GO:0043005 ISO
 Experiment description of studies that identified Iqgap1 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Iqgap1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Iqgap1 is involved
No pathways found





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