Gene description for Ifitm3
Gene name interferon induced transmembrane protein 3
Gene symbol Ifitm3
Other names/aliases DSPA2b
rat8
Species Rattus norvegicus
 Database cross references - Ifitm3
ExoCarta ExoCarta_361673
Vesiclepedia VP_361673
Entrez Gene 361673
UniProt P26376  
 Ifitm3 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Ifitm3
Biological Process
    receptor-mediated endocytosis GO:0006898 ISO
    heart development GO:0007507 IEP
    negative regulation of cell population proliferation GO:0008285 ISO
    response to virus GO:0009615 ISO
    negative regulation of viral transcription GO:0032897 ISO
    response to type II interferon GO:0034341 ISO
    response to interferon-alpha GO:0035455 ISO
    response to interferon-beta GO:0035456 ISO
    negative regulation of viral genome replication GO:0045071 ISO
    negative regulation of viral entry into host cell GO:0046597 ISO
    negative regulation of viral entry into host cell GO:0046597 ISS
    defense response to virus GO:0051607 ISO
    cardiac muscle cell differentiation GO:0055007 IEP
    type I interferon-mediated signaling pathway GO:0060337 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    lysosomal membrane GO:0005765 ISO
    lysosomal membrane GO:0005765 ISS
    endoplasmic reticulum GO:0005783 ISO
    plasma membrane GO:0005886 ISO
    cell surface GO:0009986 ISO
    cytoplasmic vesicle GO:0031410 ISO
    early endosome membrane GO:0031901 ISO
    early endosome membrane GO:0031901 ISS
    late endosome membrane GO:0031902 IEA
    protein-containing complex GO:0032991 ISO
    apical part of cell GO:0045177 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified Ifitm3 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ifitm3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Spp1  
Reconstituted Complex Rattus norvegicus
View the network image/svg+xml



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