Gene description for Ifitm3
Gene name interferon induced transmembrane protein 3
Gene symbol Ifitm3
Other names/aliases DSPA2b
rat8
Species Rattus norvegicus
 Database cross references - Ifitm3
ExoCarta ExoCarta_361673
Entrez Gene 361673
UniProt P26376  
 Ifitm3 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Ifitm3
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    response to interferon-alpha GO:0035455 ISO
    cardiac muscle cell differentiation GO:0055007 IEP
    type I interferon signaling pathway GO:0060337 ISO
    heart development GO:0007507 IEP
    negative regulation of viral entry into host cell GO:0046597 ISO
    response to virus GO:0009615 ISO
    defense response to virus GO:0051607 ISO
    receptor-mediated endocytosis GO:0006898 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    response to interferon-gamma GO:0034341 ISO
    response to interferon-beta GO:0035456 ISO
    negative regulation of viral transcription GO:0032897 ISO
    negative regulation of viral genome replication GO:0045071 ISO
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    integral component of membrane GO:0016021 IEA
    apical part of cell GO:0045177 ISO
    cell surface GO:0009986 ISO
    nucleus GO:0005634 ISO
    lysosomal membrane GO:0005765 IEA
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    late endosome membrane GO:0031902 IEA
    cellular_component GO:0005575 ND
    cytoplasmic membrane-bounded vesicle GO:0016023 ISO
 Experiment description of studies that identified Ifitm3 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ifitm3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ifitm3 is involved
PathwayEvidenceSource
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IEA Reactome





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