Gene description for Tmem109
Gene name transmembrane protein 109
Gene symbol Tmem109
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Tmem109
ExoCarta ExoCarta_361732
Vesiclepedia VP_361732
Entrez Gene 361732
UniProt Q6AYQ4  
 Tmem109 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Tmem109
Molecular Function
    voltage-gated monoatomic cation channel activity GO:0022843 ISS
Biological Process
    biological_process GO:0008150 ND
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IBA
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IEA
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 ISO
    negative regulation of programmed cell death GO:0043069 IEA
    negative regulation of programmed cell death GO:0043069 ISO
    cellular response to gamma radiation GO:0071480 IBA
    cellular response to gamma radiation GO:0071480 IEA
    cellular response to gamma radiation GO:0071480 ISO
    monoatomic cation transmembrane transport GO:0098655 IEA
Subcellular Localization
    nuclear outer membrane GO:0005640 IEA
    membrane GO:0016020 IEA
    sarcoplasmic reticulum membrane GO:0033017 ISS
    monoatomic ion channel complex GO:0034702 IEA
 Experiment description of studies that identified Tmem109 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Tmem109
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STXBP5L  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Tmem109 is involved
No pathways found





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