Gene description for Srsf3
Gene name serine/arginine-rich splicing factor 3
Gene symbol Srsf3
Other names/aliases Sfrs3
Species Rattus norvegicus
 Database cross references - Srsf3
ExoCarta ExoCarta_361814
Vesiclepedia VP_361814
Entrez Gene 361814
 Srsf3 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Srsf3
Molecular Function
    RNA binding GO:0003723 ISO
    mRNA binding GO:0003729 IBA
    pre-mRNA binding GO:0036002 ISO
    phospholipase binding GO:0043274 ISO
    primary miRNA binding GO:0070878 ISO
    protein-RNA sequence-specific adaptor activity GO:0160134 ISO
    sequence-specific mRNA binding GO:1990825 IDA
Biological Process
    mRNA processing GO:0006397 IEA
    mRNA export from nucleus GO:0006406 ISO
    biological_process GO:0008150 ND
    RNA splicing GO:0008380 IEA
    primary miRNA processing GO:0031053 ISO
    mRNA cis splicing, via spliceosome GO:0045292 IBA
    regulation of mRNA splicing, via spliceosome GO:0048024 ISO
    cellular response to leukemia inhibitory factor GO:1990830 ISO
Subcellular Localization
    nuclear speck GO:0016607 IBA
    nuclear speck GO:0016607 ISO
    nuclear speck GO:0016607 ISO
 Experiment description of studies that identified Srsf3 in sEVs
1
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Srsf3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Srsf3 is involved
No pathways found





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