Gene description for Ank3
Gene name ankyrin 3, node of Ranvier (ankyrin G)
Gene symbol Ank3
Other names/aliases ANK-3
Species Rattus norvegicus
 Database cross references - Ank3
ExoCarta ExoCarta_361833
Entrez Gene 361833
UniProt O70511  
 Ank3 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ank3
Molecular Function
    structural constituent of cytoskeleton GO:0005200 ISO
    cytoskeletal protein binding GO:0008092 IPI
    ion channel binding GO:0044325 ISO
    spectrin binding GO:0030507 IDA
    cadherin binding GO:0045296 IPI
    protein binding GO:0005515 IPI
    protein binding, bridging GO:0030674 IDA
Biological Process
    plasma membrane organization GO:0007009 ISO
    maintenance of protein location in plasma membrane GO:0072660 ISO
    signal transduction GO:0007165 IEA
    axonogenesis GO:0007409 ISO
    establishment of protein localization GO:0045184 ISO
    magnesium ion homeostasis GO:0010960 ISS
    positive regulation of cell communication by electrical coupling GO:0010650 IMP
    membrane assembly GO:0071709 ISO
    positive regulation of cation channel activity GO:2001259 IMP
    neuromuscular junction development GO:0007528 IEP
    positive regulation of sodium ion transmembrane transporter activity GO:2000651 IMP
    positive regulation of membrane potential GO:0045838 IMP
    positive regulation of sodium ion transport GO:0010765 IMP
    regulation of potassium ion transport GO:0043266 IDA
    axon guidance GO:0007411 ISO
    negative regulation of delayed rectifier potassium channel activity GO:1902260 ISS
    protein localization to plasma membrane GO:0072659 ISO
    cellular response to magnesium ion GO:0071286 ISS
    positive regulation of membrane depolarization during cardiac muscle cell action potential GO:1900827 IMP
    positive regulation of gene expression GO:0010628 IMP
    mitotic cytokinesis GO:0000281 ISO
    synapse organization GO:0050808 ISO
    protein targeting to plasma membrane GO:0072661 ISO
    Golgi to plasma membrane protein transport GO:0043001 ISO
    positive regulation of homotypic cell-cell adhesion GO:0034112 IMP
    positive regulation of protein targeting to membrane GO:0090314 IMP
    neuronal action potential GO:0019228 ISO
Subcellular Localization
    lysosome GO:0005764 IEA
    node of Ranvier GO:0033268 ISO
    plasma membrane GO:0005886 IDA
    T-tubule GO:0030315 IDA
    basal plasma membrane GO:0009925 ISO
    lateral plasma membrane GO:0016328 ISO
    bicellular tight junction GO:0005923 ISO
    sarcoplasmic reticulum GO:0016529 IDA
    cell surface GO:0009986 IDA
    paranode region of axon GO:0033270 ISO
    membrane GO:0016020 ISO
    postsynaptic membrane GO:0045211 IDA
    intracellular GO:0005622 ISO
    costamere GO:0043034 TAS
    synapse GO:0045202 ISO
    dendrite GO:0030425 IDA
    neuromuscular junction GO:0031594 IDA
    cell GO:0005623 ISO
    spectrin-associated cytoskeleton GO:0014731 IDA
    Z disc GO:0030018 IDA
    intercalated disc GO:0014704 ISO
    sarcolemma GO:0042383 ISO
    basolateral plasma membrane GO:0016323 ISO
    neuron projection GO:0043005 IDA
    axon GO:0030424 ISO
    axon initial segment GO:0043194 ISO
 Experiment description of studies that identified Ank3 in exosomes
1
Experiment ID 94
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ank3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ank3 is involved
No pathways found





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