Gene description for Aifm2
Gene name apoptosis-inducing factor, mitochondrion-associated 2
Gene symbol Aifm2
Other names/aliases Amid
Prg3
Species Rattus norvegicus
 Database cross references - Aifm2
ExoCarta ExoCarta_361843
Vesiclepedia VP_361843
Entrez Gene 361843
 Aifm2 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Aifm2
Molecular Function
    DNA binding GO:0003677 ISO
    electron-transferring-flavoprotein dehydrogenase activity GO:0004174 IBA
    electron-transferring-flavoprotein dehydrogenase activity GO:0004174 ISO
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0016655 ISO
    flavin adenine dinucleotide binding GO:0050660 IBA
    flavin adenine dinucleotide binding GO:0050660 ISO
Biological Process
    ubiquinone metabolic process GO:0006743 ISO
    apoptotic mitochondrial changes GO:0008637 IBA
    apoptotic mitochondrial changes GO:0008637 ISO
    respiratory electron transport chain GO:0022904 IEA
    vitamin K metabolic process GO:0042373 ISO
    positive regulation of apoptotic process GO:0043065 IBA
    positive regulation of apoptotic process GO:0043065 ISO
    negative regulation of ferroptosis GO:0110076 ISO
    regulation of cellular response to oxidative stress GO:1900407 ISO
    cellular detoxification GO:1990748 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISO
    mitochondrial outer membrane GO:0005741 ISO
    lipid droplet GO:0005811 ISO
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 ISO
    mitochondrial membrane GO:0031966 ISO
 Experiment description of studies that identified Aifm2 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Aifm2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aifm2 is involved
No pathways found





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