Gene description for Ppid
Gene name peptidylprolyl isomerase D
Gene symbol Ppid
Other names/aliases Cyp-40
CypD
Species Rattus norvegicus
 Database cross references - Ppid
ExoCarta ExoCarta_361967
Entrez Gene 361967
UniProt Q6DGG0  
 Ppid identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ppid
Molecular Function
    Hsp70 protein binding GO:0030544 ISS
    enzyme binding GO:0019899 IPI
    cyclosporin A binding GO:0016018 IDA
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 ISO
    estrogen receptor binding GO:0030331 ISS
    Hsp90 protein binding GO:0051879 ISS
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 ISS
    heat shock protein binding GO:0031072 ISO
Biological Process
    negative regulation of apoptotic process GO:0043066 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    chaperone-mediated protein folding GO:0061077 ISS
    lipid particle organization GO:0034389 ISS
    protein peptidyl-prolyl isomerization GO:0000413 IDA
    protein complex assembly GO:0006461 ISS
    protein transport GO:0015031 IEA
    regulation of mitochondrial membrane potential GO:0051881 IMP
    response to oxidative stress GO:0006979 IMP
    positive regulation of apoptotic process GO:0043065 ISS
    protein folding GO:0006457 ISS
    apoptotic process GO:0006915 IEA
    positive regulation of viral genome replication GO:0045070 ISO
    positive regulation of protein secretion GO:0050714 ISO
    cellular response to UV-A GO:0071492 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    nucleolus GO:0005730 ISS
    nucleoplasm GO:0005654 IEA
    mitochondrion GO:0005739 IDA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified Ppid in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ppid
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ppid is involved
No pathways found





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