Gene description for Fga
Gene name fibrinogen alpha chain
Gene symbol Fga
Other names/aliases Ac1873
Fba5e
Species Rattus norvegicus
 Database cross references - Fga
ExoCarta ExoCarta_361969
Vesiclepedia VP_361969
Entrez Gene 361969
 Fga identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Fga
Molecular Function
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    structural molecule activity GO:0005198 ISO
    protein-macromolecule adaptor activity GO:0030674 IBA
    metal ion binding GO:0046872 IEA
    cell adhesion molecule binding GO:0050839 ISO
Biological Process
    adaptive immune response GO:0002250 IEA
    acute-phase response GO:0006953 IEP
    cell-matrix adhesion GO:0007160 ISO
    blood coagulation GO:0007596 ISO
    response to toxic substance GO:0009636 IEP
    response to X-ray GO:0010165 IEP
    positive regulation of smooth muscle cell migration GO:0014911 IDA
    platelet activation GO:0030168 IEA
    plasminogen activation GO:0031639 ISO
    response to estradiol GO:0032355 IEP
    response to insulin GO:0032868 IEP
    response to genistein GO:0033595 IEP
    positive regulation of heterotypic cell-cell adhesion GO:0034116 IBA
    positive regulation of heterotypic cell-cell adhesion GO:0034116 ISO
    fibrinolysis GO:0042730 IBA
    fibrinolysis GO:0042730 ISO
    induction of bacterial agglutination GO:0043152 ISO
    envenomation resulting in modulation of blood coagulation in another organism GO:0044468 IEP
    innate immune response GO:0045087 IEA
    positive regulation of vasoconstriction GO:0045907 ISO
    positive regulation of exocytosis GO:0045921 ISO
    response to cycloheximide GO:0046898 IEP
    positive regulation of protein secretion GO:0050714 ISO
    protein polymerization GO:0051258 IEA
    protein polymerization GO:0051258 ISO
    response to calcium ion GO:0051592 ISO
    response to growth hormone GO:0060416 IEP
    protein-containing complex assembly GO:0065003 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    platelet aggregation GO:0070527 IBA
    platelet aggregation GO:0070527 ISO
    cellular response to interleukin-6 GO:0071354 IEP
    cellular response to organic cyclic compound GO:0071407 IEP
    blood coagulation, common pathway GO:0072377 IBA
    blood coagulation, common pathway GO:0072377 ISO
    blood coagulation, fibrin clot formation GO:0072378 ISO
    positive regulation of peptide hormone secretion GO:0090277 ISO
    response to thyroid hormone GO:0097066 IEP
    liver regeneration GO:0097421 IEP
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISO
    cellular response to granulocyte colony-stimulating factor GO:1990643 IEP
    negative regulation of endothelial cell apoptotic process GO:2000352 ISO
Subcellular Localization
    fibrinogen complex GO:0005577 IBA
    fibrinogen complex GO:0005577 IEA
    fibrinogen complex GO:0005577 ISO
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    endoplasmic reticulum GO:0005783 ISO
    cell cortex GO:0005938 IEA
    cell cortex GO:0005938 ISO
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 ISO
    platelet alpha granule GO:0031091 ISO
    synapse GO:0045202 IEA
    synapse GO:0045202 ISO
    blood microparticle GO:0072562 IDA
 Experiment description of studies that identified Fga in sEVs
1
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 98
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 99
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Fga
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fga is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here