Gene description for Fga
Gene name fibrinogen alpha chain
Gene symbol Fga
Other names/aliases Ac1873
Fba5e
Species Rattus norvegicus
 Database cross references - Fga
ExoCarta ExoCarta_361969
Entrez Gene 361969
 Fga identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Fga
Molecular Function
    protein binding, bridging GO:0030674 IEA
    molecular_function GO:0003674 ND
    structural molecule activity GO:0005198 ISO
    cell adhesion molecule binding GO:0050839 ISO
    receptor binding GO:0005102 ISO
Biological Process
    platelet aggregation GO:0070527 ISO
    protein polymerization GO:0051258 ISO
    acute-phase response GO:0006953 IEP
    innate immune response GO:0045087 IEA
    response to estradiol GO:0032355 IEP
    positive regulation of heterotypic cell-cell adhesion GO:0034116 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    blood coagulation, common pathway GO:0072377 ISO
    cellular response to granulocyte colony-stimulating factor GO:1990643 IEP
    cellular response to organic cyclic compound GO:0071407 IEP
    cell-matrix adhesion GO:0007160 ISO
    cellular response to interleukin-6 GO:0071354 IEP
    liver regeneration GO:0097421 IEP
    platelet activation GO:0030168 IEA
    positive regulation of protein secretion GO:0050714 ISO
    positive regulation of exocytosis GO:0045921 ISO
    response to genistein GO:0033595 IEP
    response to morphine GO:0043278 IEP
    signal transduction GO:0007165 IEA
    cellular protein complex assembly GO:0043623 ISO
    positive regulation of peptide hormone secretion GO:0090277 ISO
    cellular response to cytokine stimulus GO:0071345 IEP
    response to cycloheximide GO:0046898 IEP
    negative regulation of endothelial cell apoptotic process GO:2000352 ISO
    response to calcium ion GO:0051592 ISO
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISO
    positive regulation of vasoconstriction GO:0045907 ISO
    induction of bacterial agglutination GO:0043152 ISO
    blood coagulation GO:0007596 TAS
Subcellular Localization
    extracellular space GO:0005615 ISO
    cell surface GO:0009986 ISO
    external side of plasma membrane GO:0009897 ISO
    platelet alpha granule GO:0031091 ISO
    cell cortex GO:0005938 ISO
    extracellular exosome GO:0070062 ISO
    fibrinogen complex GO:0005577 ISO
    extracellular vesicle GO:1903561 ISO
    blood microparticle GO:0072562 ISO
    cytoplasm GO:0005737 IDA
    rough endoplasmic reticulum GO:0005791 IDA
 Experiment description of studies that identified Fga in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 99
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Fga
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fga is involved
No pathways found





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