Gene description for Pck1
Gene name	phosphoenolpyruvate carboxykinase 1 (soluble)
Gene symbol	Pck1
Other names/aliases	GTP PCK PEPCK-C Pepck RATPEPCK
Species	Rattus norvegicus
Database cross references - Pck1
ExoCarta	ExoCarta_362282
Vesiclepedia	VP_362282
Entrez Gene	362282
UniProt	P07379
Pck1 identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702

Gene ontology annotations for Pck1

Molecular Function     magnesium ion binding GO:0000287 ISO     magnesium ion binding GO:0000287 ISS     nucleoside diphosphate kinase activity GO:0004550 EXP     phosphoenolpyruvate carboxykinase activity GO:0004611 IDA     phosphoenolpyruvate carboxykinase activity GO:0004611 ISO     phosphoenolpyruvate carboxykinase (GTP) activity GO:0004613 IBA     phosphoenolpyruvate carboxykinase (GTP) activity GO:0004613 IDA     phosphoenolpyruvate carboxykinase (GTP) activity GO:0004613 ISO     GTP binding GO:0005525 IDA     GTP binding GO:0005525 ISO     GDP binding GO:0019003 IDA     manganese ion binding GO:0030145 IBA     manganese ion binding GO:0030145 IDA     manganese ion binding GO:0030145 ISO     carboxylic acid binding GO:0031406 IDA     carboxylic acid binding GO:0031406 ISO     protein serine kinase activity (using GTP as donor) GO:0106264 ISO     protein serine kinase activity (using GTP as donor) GO:0106264 ISS Biological Process     glucose metabolic process GO:0006006 IMP     glucose metabolic process GO:0006006 ISO     gluconeogenesis GO:0006094 IBA     gluconeogenesis GO:0006094 IDA     gluconeogenesis GO:0006094 IEA     gluconeogenesis GO:0006094 ISO     gluconeogenesis GO:0006094 ISO     gluconeogenesis GO:0006094 TAS     oxaloacetate metabolic process GO:0006107 IBA     oxaloacetate metabolic process GO:0006107 IDA     oxaloacetate metabolic process GO:0006107 ISO     lipid metabolic process GO:0006629 ISO     response to bacterium GO:0009617 ISO     response to activity GO:0014823 IEP     peptidyl-serine phosphorylation GO:0018105 ISO     peptidyl-serine phosphorylation GO:0018105 ISS     propionate catabolic process GO:0019543 IBA     response to nutrient levels GO:0031667 IEP     response to lipopolysaccharide GO:0032496 IEP     response to insulin GO:0032868 ISO     response to insulin GO:0032868 ISS     cellular response to insulin stimulus GO:0032869 IBA     cellular response to insulin stimulus GO:0032869 IEP     cellular response to insulin stimulus GO:0032869 ISO     cellular response to insulin stimulus GO:0032869 ISS     response to lipid GO:0033993 IEP     glucose homeostasis GO:0042593 IDA     response to starvation GO:0042594 IBA     positive regulation of memory T cell differentiation GO:0043382 ISO     positive regulation of memory T cell differentiation GO:0043382 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     glyceraldehyde-3-phosphate biosynthetic process GO:0046166 ISO     glycerol biosynthetic process from pyruvate GO:0046327 IBA     glycerol biosynthetic process from pyruvate GO:0046327 IDA     glycerol biosynthetic process from pyruvate GO:0046327 ISO     positive regulation of lipid biosynthetic process GO:0046889 ISO     regulation of lipid biosynthetic process GO:0046890 ISO     regulation of lipid biosynthetic process GO:0046890 ISS     cellular response to potassium ion starvation GO:0051365 ISO     hepatocyte differentiation GO:0070365 IBA     response to interleukin-6 GO:0070741 IEP     cellular response to retinoic acid GO:0071300 IEP     cellular response to cAMP GO:0071320 IEP     cellular response to fructose stimulus GO:0071332 IEP     cellular response to glucose stimulus GO:0071333 IBA     cellular response to glucose stimulus GO:0071333 IDA     cellular response to glucose stimulus GO:0071333 ISO     cellular response to interleukin-1 GO:0071347 IEP     cellular response to tumor necrosis factor GO:0071356 IEP     cellular response to glucagon stimulus GO:0071377 IEP     cellular response to hypoxia GO:0071456 IEP     cellular hyperosmotic response GO:0071474 IEP     cellular hyperosmotic salinity response GO:0071475 IEP     cellular hypotonic response GO:0071476 IEP     cellular hypotonic salinity response GO:0071477 IEP     cellular response to dexamethasone stimulus GO:0071549 IBA     tricarboxylic acid metabolic process GO:0072350 ISO     cellular response to raffinose GO:0097403 IEP     cellular response to phorbol 13-acetate 12-myristate GO:1904628 IEP     response to methionine GO:1904640 IEP Subcellular Localization     cytoplasm GO:0005737 IDA     mitochondrion GO:0005739 IBA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum GO:0005783 ISS     cytosol GO:0005829 IBA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     cytosol GO:0005829 TAS