ExoCarta: Gene summary

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Gene description for Hnrnpa2b1
Gene name	heterogeneous nuclear ribonucleoprotein A2/B1
Gene symbol	Hnrnpa2b1
Other names/aliases	Hnrpa2 Hnrpa2b1 hnRNP
Species	Rattus norvegicus
Database cross references - Hnrnpa2b1
ExoCarta	ExoCarta_362361
Entrez Gene	362361
UniProt	A7VJC2
Hnrnpa2b1 identified in exosomes derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Hnrnpa2b1

Molecular Function
	RNA binding	GO:0003723	ISO
	nucleotide binding	GO:0000166	IEA
	poly(A) RNA binding	GO:0044822	ISO
	pre-mRNA intronic binding	GO:0097157	ISO
	single-stranded telomeric DNA binding	GO:0043047	ISO
	nucleic acid binding	GO:0003676	IEA
	regulatory region RNA binding	GO:0001069	IDA
Biological Process
	male gonad development	GO:0008584	IEP
	lung development	GO:0030324	IEP
	RNA splicing	GO:0008380	IEA
	mRNA processing	GO:0006397	ISO
	RNA transport	GO:0050658	ISO
	negative regulation of mRNA splicing, via spliceosome	GO:0048025	ISO
	oligodendrocyte differentiation	GO:0048709	IEP
	response to mineralocorticoid	GO:0051385	IEP
	negative regulation of transcription from RNA polymerase II promoter	GO:0000122	ISO
Subcellular Localization
	spliceosomal complex	GO:0005681	ISO
	cytoplasm	GO:0005737	IDA
	membrane	GO:0016020	ISO
	ribonucleoprotein complex	GO:0030529	ISS
	chromatin	GO:0000785	IDA
	neuron projection	GO:0043005	IDA
	nucleus	GO:0005634	ISO
	catalytic step 2 spliceosome	GO:0071013	ISO
	neuronal cell body	GO:0043025	IDA
	neuronal ribonucleoprotein granule	GO:0071598	IDA
	perikaryon	GO:0043204	IDA
	nucleoplasm	GO:0005654	IEA

Experiment description of studies that identified Hnrnpa2b1 in exosomes

Experiment ID

ISEV standards
✔ EM	EV Biophysical techniques
✔ TSG101\|HSP90\|HSC70	EV Cytosolic markers
✔ MHCI	EV Membrane markers
✘	EV Negative markers
✘	EV Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry [Orbitrap]

PubMed ID

21828046

Organism

Rattus norvegicus

Experiment description

The proteo-lipidic composition of exosomes changes during reticulocyte maturation.

Authors

Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.

Journal name

JBC

Publication year

2011

Sample

Reticulocytes

Sample name

Reticulocytes - D2 Rep 2

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.16-1.21 g/mL

Molecules identified in the study

Protein
Lipids

Methods used in the study

Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting