Gene description for Kpna6
Gene name karyopherin alpha 6 (importin alpha 7)
Gene symbol Kpna6
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Kpna6
ExoCarta ExoCarta_362607
Entrez Gene 362607
 Kpna6 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Kpna6
Molecular Function
    protein transporter activity GO:0008565 ISO
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    maternal process involved in female pregnancy GO:0060135 ISO
    protein import into nucleus GO:0006606 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cell GO:0005623 ISO
    membrane GO:0016020 ISO
    intracellular GO:0005622 ISO
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Kpna6 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Kpna6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Kpna6 is involved
No pathways found





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