Gene description for Kpna6
Gene name karyopherin alpha 6 (importin alpha 7)
Gene symbol Kpna6
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Kpna6
ExoCarta ExoCarta_362607
Vesiclepedia VP_362607
Entrez Gene 362607
 Kpna6 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Kpna6
Molecular Function
    nuclear localization sequence binding GO:0008139 IBA
    nuclear import signal receptor activity GO:0061608 IBA
    nuclear import signal receptor activity GO:0061608 ISO
Biological Process
    transcription by RNA polymerase II GO:0006366 ISO
    protein import into nucleus GO:0006606 ISO
    NLS-bearing protein import into nucleus GO:0006607 IBA
    viral genome replication GO:0019079 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    maternal process involved in female pregnancy GO:0060135 ISO
    entry of viral genome into host nucleus through nuclear pore complex via importin GO:0075506 ISO
    positive regulation of cytokine production involved in inflammatory response GO:1900017 ISO
    positive regulation of viral life cycle GO:1903902 ISO
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IBA
    cytoplasm GO:0005737 IEA
    NLS-dependent protein nuclear import complex GO:0042564 ISO
    host cell GO:0043657 IEA
 Experiment description of studies that identified Kpna6 in sEVs
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Kpna6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Kpna6 is involved
No pathways found





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