Gene description for Mbip
Gene name MAP3K12 binding inhibitory protein 1
Gene symbol Mbip
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Mbip
ExoCarta ExoCarta_362740
Vesiclepedia VP_362740
Entrez Gene 362740
 Mbip identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Mbip
Molecular Function
    protein kinase inhibitor activity GO:0004860 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    regulation of DNA-templated transcription GO:0006355 ISO
    regulation of transcription by RNA polymerase II GO:0006357 ISO
    biological_process GO:0008150 ND
    positive regulation of gene expression GO:0010628 ISO
    regulation of embryonic development GO:0045995 ISO
    positive regulation of JNK cascade GO:0046330 ISO
    regulation of cell division GO:0051302 ISO
    regulation of cell cycle GO:0051726 ISO
    regulation of tubulin deacetylation GO:0090043 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    ATAC complex GO:0140672 ISO
 Experiment description of studies that identified Mbip in sEVs
1
Experiment ID 101
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Mbip
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mbip is involved
No pathways found





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