Gene description for Tmx1
Gene name thioredoxin-related transmembrane protein 1
Gene symbol Tmx1
Other names/aliases Txndc1
Species Rattus norvegicus
 Database cross references - Tmx1
ExoCarta ExoCarta_362751
Vesiclepedia VP_362751
Entrez Gene 362751
 Tmx1 identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Tmx1
Molecular Function
    protein disulfide isomerase activity GO:0003756 ISO
    enzyme inhibitor activity GO:0004857 ISO
    protein-disulfide reductase activity GO:0015035 ISO
    disulfide oxidoreductase activity GO:0015036 IBA
    disulfide oxidoreductase activity GO:0015036 ISO
Biological Process
    negative regulation of triglyceride biosynthetic process GO:0010868 ISO
    response to endoplasmic reticulum stress GO:0034976 ISO
    regulation of calcium ion transport GO:0051924 ISO
    negative regulation of platelet aggregation GO:0090331 ISO
    positive regulation of ERAD pathway GO:1904294 ISO
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 ISO
    endoplasmic reticulum membrane GO:0005789 ISO
    endomembrane system GO:0012505 IBA
    mitochondria-associated endoplasmic reticulum membrane contact site GO:0044233 ISO
 Experiment description of studies that identified Tmx1 in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Tmx1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmx1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here