Gene description for Slc44a2
Gene name solute carrier family 44 (choline transporter), member 2
Gene symbol Slc44a2
Other names/aliases RGD1309680
Species Rattus norvegicus
 Database cross references - Slc44a2
ExoCarta ExoCarta_363024
Vesiclepedia VP_363024
Entrez Gene 363024
UniProt B4F795  
 Slc44a2 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Slc44a2
Molecular Function
    organic cation transmembrane transporter activity GO:0015101 IEA
    choline transmembrane transporter activity GO:0015220 IEA
    choline transmembrane transporter activity GO:0015220 ISO
    choline transmembrane transporter activity GO:0015220 ISO
    choline transmembrane transporter activity GO:0015220 ISS
    antiporter activity GO:0015297 IEA
    transmembrane transporter activity GO:0022857 IBA
    ethanolamine transmembrane transporter activity GO:0034228 IEA
    ethanolamine transmembrane transporter activity GO:0034228 ISO
    ethanolamine transmembrane transporter activity GO:0034228 ISS
Biological Process
    organic cation transport GO:0015695 IEA
    choline transport GO:0015871 IEA
    choline transport GO:0015871 ISO
    choline transport GO:0015871 ISO
    choline transport GO:0015871 ISS
    ethanolamine transport GO:0034229 IEA
    ethanolamine transport GO:0034229 ISO
    ethanolamine transport GO:0034229 ISS
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    transmembrane transport GO:0055085 IBA
    transmembrane transport GO:0055085 IEA
    transmembrane transport GO:0055085 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    mitochondrial outer membrane GO:0005741 IEA
    mitochondrial outer membrane GO:0005741 ISO
    mitochondrial outer membrane GO:0005741 ISS
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 IBA
 Experiment description of studies that identified Slc44a2 in sEVs
1
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc44a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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