Gene description for Cops8
Gene name COP9 signalosome subunit 8
Gene symbol Cops8
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Cops8
ExoCarta ExoCarta_363283
Vesiclepedia VP_363283
Entrez Gene 363283
UniProt Q6P4Z9  
 Cops8 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Cops8
Biological Process
    protein deneddylation GO:0000338 IEA
    protein deneddylation GO:0000338 ISO
    protein phosphorylation GO:0006468 ISO
    activation of NF-kappaB-inducing kinase activity GO:0007250 ISO
    negative regulation of cell population proliferation GO:0008285 ISO
    COP9 signalosome assembly GO:0010387 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    COP9 signalosome GO:0008180 IBA
    COP9 signalosome GO:0008180 IEA
    COP9 signalosome GO:0008180 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Cops8 in sEVs
1
Experiment ID 98
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cops8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here