Gene description for Cops8
Gene name COP9 signalosome subunit 8
Gene symbol Cops8
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Cops8
ExoCarta ExoCarta_363283
Entrez Gene 363283
UniProt Q6P4Z9  
 Cops8 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Cops8
Biological Process
    activation of NF-kappaB-inducing kinase activity GO:0007250 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    cullin deneddylation GO:0010388 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
    COP9 signalosome GO:0008180 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Cops8 in exosomes
1
Experiment ID 98
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Cops8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cops8 is involved
No pathways found





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