Gene description for Chmp2a
Gene name charged multivesicular body protein 2A
Gene symbol Chmp2a
Other names/aliases RGD1305050
Species Rattus norvegicus
 Database cross references - Chmp2a
ExoCarta ExoCarta_365191
Entrez Gene 365191
 Chmp2a identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Chmp2a
Molecular Function
    protein domain specific binding GO:0019904 ISO
    phosphatidylcholine binding GO:0031210 ISO
Biological Process
    membrane invagination GO:0010324 ISO
    protein heterooligomerization GO:0051291 ISO
    regulation of centrosome duplication GO:0010824 ISO
    cell separation after cytokinesis GO:0000920 ISO
    regulation of viral process GO:0050792 ISO
    positive regulation of exosomal secretion GO:1903543 ISO
    negative regulation of cell death GO:0060548 ISO
    protein homooligomerization GO:0051260 ISO
    positive regulation of viral release from host cell GO:1902188 ISO
    nucleus organization GO:0006997 ISO
    viral budding via host ESCRT complex GO:0039702 ISO
    regulation of mitotic spindle assembly GO:1901673 ISO
    vacuolar transport GO:0007034 IEA
    mitotic metaphase plate congression GO:0007080 ISO
    protein polymerization GO:0051258 ISO
    establishment of protein localization GO:0045184 ISO
    negative regulation of centriole elongation GO:1903723 ISO
Subcellular Localization
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
    cytosol GO:0005829 ISO
    membrane coat GO:0030117 ISO
 Experiment description of studies that identified Chmp2a in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Chmp2a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Chmp2a is involved
No pathways found





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