Gene description for Pttg1ip
Gene name pituitary tumor-transforming 1 interacting protein
Gene symbol Pttg1ip
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pttg1ip
ExoCarta ExoCarta_365548
Entrez Gene 365548
UniProt Q6P767  
 Pttg1ip identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Pttg1ip
Molecular Function
    p53 binding GO:0002039 ISO
Biological Process
    positive regulation of cellular protein catabolic process GO:1903364 ISO
    positive regulation of protein ubiquitination GO:0031398 ISO
    protein import into nucleus GO:0006606 ISO
    negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 ISO
    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 ISO
Subcellular Localization
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 ISO
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 ISO
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Pttg1ip in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Pttg1ip
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pttg1ip is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here