Gene description for Bhmt2
Gene name betaine-homocysteine S-methyltransferase 2
Gene symbol Bhmt2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Bhmt2
ExoCarta ExoCarta_365972
Vesiclepedia VP_365972
Entrez Gene 365972
UniProt Q68FT5  
 Bhmt2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Bhmt2
Molecular Function
    S-methyltransferase activity GO:0008172 IEA
    zinc ion binding GO:0008270 IEA
    zinc ion binding GO:0008270 ISO
    S-adenosylmethionine-homocysteine S-methyltransferase activity GO:0008898 IEA
    betaine-homocysteine S-methyltransferase activity GO:0047150 ISO
    S-methylmethionine-homocysteine S-methyltransferase activity GO:0061627 IBA
    S-methylmethionine-homocysteine S-methyltransferase activity GO:0061627 IEA
    S-methylmethionine-homocysteine S-methyltransferase activity GO:0061627 ISO
Biological Process
    amino-acid betaine metabolic process GO:0006577 ISO
    methionine biosynthetic process GO:0009086 IEA
    methylation GO:0032259 IEA
    S-methylmethionine metabolic process GO:0033477 IEA
    S-methylmethionine metabolic process GO:0033477 ISO
    S-adenosylmethionine metabolic process GO:0046500 IEA
    S-adenosylmethionine metabolic process GO:0046500 ISO
    L-methionine salvage GO:0071267 IBA
    L-methionine salvage GO:0071267 IEA
    L-methionine salvage GO:0071267 ISO
Subcellular Localization
    cytosol GO:0005829 IBA
 Experiment description of studies that identified Bhmt2 in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Bhmt2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Bhmt2 is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Sulfur amino acid metabolism IEA Reactome





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