Gene description for Cfl2
Gene name cofilin 2, muscle
Gene symbol Cfl2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Cfl2
ExoCarta ExoCarta_366624
Vesiclepedia VP_366624
Entrez Gene 366624
 Cfl2 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Cfl2
Molecular Function
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 ISO
Biological Process
    actin filament organization GO:0007015 ISO
    skeletal muscle tissue development GO:0007519 ISO
    actin filament depolymerization GO:0030042 ISO
    actin filament depolymerization GO:0030042 ISO
    actin filament fragmentation GO:0030043 IBA
    actin filament fragmentation GO:0030043 ISO
    positive regulation of actin filament depolymerization GO:0030836 ISO
    sarcomere organization GO:0045214 ISO
    muscle cell cellular homeostasis GO:0046716 ISO
    actin filament severing GO:0051014 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    actin cytoskeleton GO:0015629 IBA
    nuclear matrix GO:0016363 IEA
    Z disc GO:0030018 ISO
    I band GO:0031674 ISO
 Experiment description of studies that identified Cfl2 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Cfl2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cfl2 is involved
No pathways found





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