Gene description for Fbxo7
Gene name F-box protein 7
Gene symbol Fbxo7
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Fbxo7
ExoCarta ExoCarta_366854
Entrez Gene 366854
UniProt Q68FS3  
 Fbxo7 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Fbxo7
Molecular Function
    protein kinase binding GO:0019901 ISO
Biological Process
    protein ubiquitination GO:0016567 ISS
    negative regulation of lymphocyte differentiation GO:0045620 ISO
    regulation of protein stability GO:0031647 ISO
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 ISO
    protein targeting to mitochondrion GO:0006626 ISS
    mitochondrion degradation GO:0000422 ISS
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISS
    ubiquitin ligase complex GO:0000151 ISS
    protein complex GO:0043234 ISO
    mitochondrion GO:0005739 ISS
 Experiment description of studies that identified Fbxo7 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Fbxo7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fbxo7 is involved
No pathways found





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