Gene description for Fbxo7
Gene name F-box protein 7
Gene symbol Fbxo7
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Fbxo7
ExoCarta ExoCarta_366854
Vesiclepedia VP_366854
Entrez Gene 366854
UniProt Q68FS3  
 Fbxo7 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Fbxo7
Molecular Function
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    ubiquitin binding GO:0043130 ISO
    protein heterodimerization activity GO:0046982 ISO
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 ISO
Biological Process
    autophagy of mitochondrion GO:0000422 ISO
    autophagy of mitochondrion GO:0000422 ISS
    ubiquitin-dependent protein catabolic process GO:0006511 ISO
    protein targeting to mitochondrion GO:0006626 ISO
    protein targeting to mitochondrion GO:0006626 ISS
    biological_process GO:0008150 ND
    regulation of neuron projection development GO:0010975 ISO
    protein ubiquitination GO:0016567 ISO
    protein ubiquitination GO:0016567 ISS
    lymphocyte differentiation GO:0030098 ISO
    regulation of protein stability GO:0031647 ISO
    regulation of locomotion GO:0040012 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    negative regulation of neuron apoptotic process GO:0043524 IMP
    negative regulation of lymphocyte differentiation GO:0045620 ISO
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 ISO
    protein K48-linked ubiquitination GO:0070936 ISO
    positive regulation of mitophagy GO:1901526 IMP
    positive regulation of mitophagy GO:1901526 ISO
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 ISO
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 ISO
    positive regulation of autophagy of mitochondrion GO:1903599 IBA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 ISO
Subcellular Localization
    ubiquitin ligase complex GO:0000151 ISO
    ubiquitin ligase complex GO:0000151 ISS
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 ISO
    mitochondrion GO:0005739 ISS
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    SCF ubiquitin ligase complex GO:0019005 ISO
    protein-containing complex GO:0032991 ISO
    glial cytoplasmic inclusion GO:0097409 ISO
    classical Lewy body GO:0097414 ISO
    Lewy neurite GO:0097462 ISO
    Lewy body core GO:1990037 ISO
    Lewy body corona GO:1990038 ISO
 Experiment description of studies that identified Fbxo7 in sEVs
1
Experiment ID 95
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Fbxo7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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