Gene description for Lrg1
Gene name leucine-rich alpha-2-glycoprotein 1
Gene symbol Lrg1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lrg1
ExoCarta ExoCarta_367455
Entrez Gene 367455
 Lrg1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Lrg1
Molecular Function
    transforming growth factor beta receptor binding GO:0005160 ISO
Biological Process
    positive regulation of angiogenesis GO:0045766 ISO
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 ISO
    positive regulation of endothelial cell proliferation GO:0001938 ISO
    brown fat cell differentiation GO:0050873 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Lrg1 in exosomes
1
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Lrg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lrg1 is involved
No pathways found





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