Gene description for Lrg1
Gene name leucine-rich alpha-2-glycoprotein 1
Gene symbol Lrg1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lrg1
ExoCarta ExoCarta_367455
Vesiclepedia VP_367455
Entrez Gene 367455
 Lrg1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Lrg1
Molecular Function
    type II transforming growth factor beta receptor binding GO:0005114 ISO
    transforming growth factor beta receptor binding GO:0005160 ISO
    voltage-gated potassium channel activity GO:0005249 IBA
    type I transforming growth factor beta receptor binding GO:0034713 ISO
    transmembrane transporter binding GO:0044325 IBA
    potassium channel activator activity GO:0099104 IBA
Biological Process
    positive regulation of endothelial cell proliferation GO:0001938 ISO
    positive regulation of endothelial cell proliferation GO:0001938 ISO
    response to bacterium GO:0009617 ISO
    positive regulation of epithelial to mesenchymal transition GO:0010718 ISO
    positive regulation of keratinocyte proliferation GO:0010838 ISO
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 ISO
    positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 ISO
    wound healing, spreading of epidermal cells GO:0035313 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    brown fat cell differentiation GO:0050873 ISO
    keratinocyte migration GO:0051546 ISO
    positive regulation of epithelial cell proliferation involved in wound healing GO:0060054 ISO
    leukocyte adhesion to vascular endothelial cell GO:0061756 ISO
    potassium ion transmembrane transport GO:0071805 IEA
Subcellular Localization
    extracellular space GO:0005615 ISO
    voltage-gated potassium channel complex GO:0008076 IBA
    intracellular membrane-bounded organelle GO:0043231 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Lrg1 in sEVs
1
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Lrg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lrg1 is involved
No pathways found





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