Gene description for Khc
Gene name Kinesin heavy chain
Gene symbol Khc
Other names/aliases CG7765
DK
DKH
DmK
DmKHC
DmelCG7765
Dmkin
KHC
KIF 5A
KIF5B
KIN
Kin
Kin-1
Kinesin-1
khc
kin
kinesin
kinesin-1
l(2)W12
l(2)k13219
l(2)k13314
l(2R)W12
pgs
Species Drosophila melanogaster
 Database cross references - Khc
ExoCarta ExoCarta_36810
Entrez Gene 36810
UniProt P17210  
 Khc identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Khc
Molecular Function
    ATP binding GO:0005524 IEA
    ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 TAS
    microtubule binding GO:0008017 ISS
    motor activity GO:0003774 NAS
    microtubule motor activity GO:0003777 NAS
Biological Process
    oocyte microtubule cytoskeleton polarization GO:0008103 IMP
    neuronal action potential propagation GO:0019227 NAS
    cytoplasmic transport, nurse cell to oocyte GO:0007303 TAS
    oocyte dorsal/ventral axis specification GO:0007310 IMP
    axon cargo transport GO:0008088 IMP
    maintenance of cell polarity GO:0030011 IMP
    axonogenesis GO:0007409 IMP
    establishment of nucleus localization GO:0040023 IMP
    microtubule sliding GO:0051012 IMP
    actin filament bundle organization GO:0061572 IMP
    larval locomotory behavior GO:0008345 IMP
    microtubule-based transport GO:0010970 IDA
    axon guidance GO:0007411 IMP
    pole plasm oskar mRNA localization GO:0045451 NAS
    centrosome separation GO:0051299 IMP
    pole plasm assembly GO:0007315 IMP
    eye photoreceptor cell differentiation GO:0001754 IGI
    intracellular distribution of mitochondria GO:0048312 IMP
    microtubule polymerization GO:0046785 IMP
    neuron projection morphogenesis GO:0048812 IMP
    mitochondrion transport along microtubule GO:0047497 IMP
    skeletal muscle fiber development GO:0048741 IMP
    dendrite morphogenesis GO:0048813 IMP
    cytoplasmic transport GO:0016482 IMP
    microtubule-based movement GO:0007018 NAS
    neurotransmitter secretion GO:0007269 NAS
    mitochondrion distribution GO:0048311 IMP
    regulation of pole plasm oskar mRNA localization GO:0007317 TAS
    dorsal appendage formation GO:0046843 IMP
    intracellular protein transport GO:0006886 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    microtubule associated complex GO:0005875 IDA
    mitochondrion GO:0005739 IDA
    kinesin complex GO:0005871 NAS
    microtubule plus-end GO:0035371 IDA
 Experiment description of studies that identified Khc in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Khc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Khc is involved
PathwayEvidenceSource
Kinesins IEA Reactome
RHO GTPases activate KTN1 IEA Reactome





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