Gene description for cora
Gene name coracle
Gene symbol cora
Other names/aliases CG11949
COR
Cor
Cora
Coracle
D4.1
DmelCG11949
cor
l(2)k08713
Species Drosophila melanogaster
 Database cross references - cora
ExoCarta ExoCarta_37205
Vesiclepedia VP_37205
Entrez Gene 37205
UniProt Q9V8R9  
 cora identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for cora
Biological Process
    heart process GO:0003015 IMP
    protein targeting to membrane GO:0006612 TAS
    dorsal closure GO:0007391 IMP
    dorsal closure GO:0007391 TAS
    adult somatic muscle development GO:0007527 IMP
    embryo development ending in birth or egg hatching GO:0009792 IMP
    regulation of tube size, open tracheal system GO:0035151 IMP
    maintenance of imaginal disc-derived wing hair orientation GO:0035321 IMP
    cell-cell junction organization GO:0045216 TAS
    establishment of glial blood-brain barrier GO:0060857 IMP
    cell adhesion involved in heart morphogenesis GO:0061343 IMP
Subcellular Localization
    plasma membrane GO:0005886 IDA
    septate junction GO:0005918 IDA
    smooth septate junction GO:0005920 IDA
 Experiment description of studies that identified cora in sEVs
1
Experiment ID 202
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG10|RAB35|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for cora
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pms2  
Two-hybrid Drosophila melanogaster
2 rau  
Two-hybrid Drosophila melanogaster
3 dgt2  
Affinity Capture-MS Drosophila melanogaster
4 Mer  
Two-hybrid Drosophila melanogaster
5 CG9636  
Two-hybrid Drosophila melanogaster
6 Ssu72  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml
 Pathways in which cora is involved
PathwayEvidenceSource
Neurexins and neuroligins IEA Reactome
Neuronal System IEA Reactome
Protein-protein interactions at synapses IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here