Gene description for Vps20
Gene name Vacuolar protein sorting 20
Gene symbol Vps20
Other names/aliases CG4071
DmVPS20
DmelCG4071
ESCRT-III
anon-EST:Posey40
vps20
Species Drosophila melanogaster
 Database cross references - Vps20
ExoCarta ExoCarta_37581
Entrez Gene 37581
 Vps20 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Vps20
Molecular Function
    molecular_function GO:0003674 ND
Biological Process
    germarium-derived egg chamber formation GO:0007293 IMP
    vacuolar transport GO:0007034 IEA
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    regulation of Notch signaling pathway GO:0008593 IMP
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IMP
    negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 IMP
    epithelium development GO:0060429 IMP
    ovarian follicle cell stalk formation GO:0030713 IMP
    endosome transport via multivesicular body sorting pathway GO:0032509 IMP
Subcellular Localization
    ESCRT III complex GO:0000815 ISS
 Experiment description of studies that identified Vps20 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Vps20
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Vps20 is involved
No pathways found





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