Gene description for Terc
Gene name telomerase RNA component
Gene symbol Terc
Other names/aliases Tr
Species Rattus norvegicus
 Database cross references - Terc
ExoCarta ExoCarta_378461
Vesiclepedia VP_378461
Entrez Gene 378461
 Terc identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Terc
Molecular Function
    template for synthesis of G-rich strand of telomere DNA activity GO:0000332 ISO
    template for synthesis of G-rich strand of telomere DNA activity GO:0000332 TAS
    telomerase activity GO:0003720 ISO
    telomerase activity GO:0003720 ISO
    RNA-directed DNA polymerase activity GO:0003964 ISO
    protein-containing complex binding GO:0044877 ISO
    DNA polymerase binding GO:0070182 ISO
    WD40-repeat domain binding GO:0071987 ISO
Biological Process
    telomere maintenance GO:0000723 ISO
    telomere maintenance via telomerase GO:0007004 ISO
    telomere maintenance via telomerase GO:0007004 ISO
    telomere maintenance via telomerase GO:0007004 TAS
    determination of adult lifespan GO:0008340 ISO
    post-embryonic development GO:0009791 ISO
    positive regulation of telomere maintenance via telomerase GO:0032212 ISO
    regulation of cell population proliferation GO:0042127 ISO
    negative regulation of cell differentiation GO:0045596 IMP
    hematopoietic stem cell differentiation GO:0060218 ISO
    hematopoietic stem cell proliferation GO:0071425 ISO
    cellular response to hypoxia GO:0071456 ISO
    negative regulation of cellular senescence GO:2000773 ISO
Subcellular Localization
    telomerase catalytic core complex GO:0000333 ISO
    chromosome, telomeric region GO:0000781 ISO
    telomerase holoenzyme complex GO:0005697 ISO
    cytoplasm GO:0005737 ISO
    Cajal body GO:0015030 ISO
    box H/ACA telomerase RNP complex GO:0090661 ISO
 Experiment description of studies that identified Terc in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Terc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Terc is involved
No pathways found





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