Gene description for Kif14
Gene name kinesin family member 14
Gene symbol Kif14
Other names/aliases D1Ertd367e
E130203M01
Species Mus musculus
 Database cross references - Kif14
ExoCarta ExoCarta_381293
Vesiclepedia VP_381293
Entrez Gene 381293
UniProt L0N7N1  
 Kif14 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Kif14
Molecular Function
    protein kinase binding GO:0019901 ISO
    ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 IDA
    ATP binding GO:0005524 IDA
    microtubule binding GO:0008017 IDA
    tubulin binding GO:0015631 IDA
    nucleotide binding GO:0000166 IEA
    PDZ domain binding GO:0030165 ISO
    ATPase activity GO:0016887 IDA
    microtubule motor activity GO:0003777 IEA
Biological Process
    cytoskeleton-dependent intracellular transport GO:0030705 IBA
    regulation of G1/S transition of mitotic cell cycle GO:2000045 ISO
    cell division GO:0051301 IMP
    cerebellar cortex development GO:0021695 IMP
    regulation of cell maturation GO:1903429 IMP
    negative regulation of apoptotic process GO:0043066 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    regulation of cell adhesion GO:0030155 ISO
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISO
    cerebral cortex development GO:0021987 IMP
    regulation of cell migration GO:0030334 ISO
    mitotic cell cycle process GO:1903047 ISO
    negative regulation of integrin activation GO:0033624 ISO
    regulation of myelination GO:0031641 IMP
    mitotic metaphase plate congression GO:0007080 ISO
    cerebellar granular layer structural organization GO:0021685 IMP
    olfactory bulb development GO:0021772 IMP
    hippocampus development GO:0021766 IMP
    establishment of protein localization GO:0045184 ISO
    cerebellar Purkinje cell layer structural organization GO:0021693 IMP
    regulation of Rap protein signal transduction GO:0032487 ISO
    microtubule depolymerization GO:0007019 IDA
    regulation of G2/M transition of mitotic cell cycle GO:0010389 ISO
    regulation of cell growth GO:0001558 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of cytokinesis GO:0032467 ISO
    activation of protein kinase activity GO:0032147 ISO
    regulation of neuron apoptotic process GO:0043523 IMP
    negative regulation of neuron apoptotic process GO:0043524 IMP
    cell proliferation in forebrain GO:0021846 IMP
    microtubule-based movement GO:0007018 IBA
    substrate adhesion-dependent cell spreading GO:0034446 ISO
Subcellular Localization
    midbody GO:0030496 ISO
    cytoplasm GO:0005737 IEA
    microtubule GO:0005874 ISO
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
    cytoskeleton GO:0005856 IEA
    kinesin complex GO:0005871 IBA
    spindle midzone GO:0051233 ISO
    nucleus GO:0005634 IEA
 Experiment description of studies that identified Kif14 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Kif14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Kif14 is involved
PathwayEvidenceSource
RHO GTPases activate CIT IEA Reactome





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