Gene description for Kif14
Gene name kinesin family member 14
Gene symbol Kif14
Other names/aliases D1Ertd367e
E130203M01
Species Mus musculus
 Database cross references - Kif14
ExoCarta ExoCarta_381293
Vesiclepedia VP_381293
Entrez Gene 381293
UniProt L0N7N1  
 Kif14 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Kif14
Molecular Function
    microtubule motor activity GO:0003777 IBA
    ATP binding GO:0005524 IDA
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 IDA
    plus-end-directed microtubule motor activity GO:0008574 IDA
    tubulin binding GO:0015631 IDA
    ATP hydrolysis activity GO:0016887 IBA
    ATP hydrolysis activity GO:0016887 IDA
    protein kinase binding GO:0019901 IEA
    protein kinase binding GO:0019901 ISO
    PDZ domain binding GO:0030165 ISO
Biological Process
    regulation of cell growth GO:0001558 ISO
    regulation of cell growth GO:0001558 ISS
    microtubule-based movement GO:0007018 IBA
    microtubule-based movement GO:0007018 IEA
    microtubule depolymerization GO:0007019 IDA
    mitotic metaphase chromosome alignment GO:0007080 ISO
    mitotic metaphase chromosome alignment GO:0007080 ISS
    positive regulation of cell population proliferation GO:0008284 ISO
    positive regulation of cell population proliferation GO:0008284 ISS
    regulation of G2/M transition of mitotic cell cycle GO:0010389 ISO
    regulation of G2/M transition of mitotic cell cycle GO:0010389 ISS
    cerebellar granular layer structural organization GO:0021685 IMP
    cerebellar Purkinje cell layer structural organization GO:0021693 IMP
    cerebellar cortex development GO:0021695 IMP
    hippocampus development GO:0021766 IMP
    olfactory bulb development GO:0021772 IMP
    cell proliferation in forebrain GO:0021846 IMP
    cerebral cortex development GO:0021987 IMP
    regulation of cell adhesion GO:0030155 ISO
    regulation of cell migration GO:0030334 ISO
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISO
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISS
    regulation of myelination GO:0031641 IMP
    activation of protein kinase activity GO:0032147 ISO
    activation of protein kinase activity GO:0032147 ISS
    positive regulation of cytokinesis GO:0032467 ISO
    positive regulation of cytokinesis GO:0032467 ISS
    regulation of Rap protein signal transduction GO:0032487 ISO
    negative regulation of integrin activation GO:0033624 ISO
    substrate adhesion-dependent cell spreading GO:0034446 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of apoptotic process GO:0043066 ISS
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    regulation of neuron apoptotic process GO:0043523 IMP
    negative regulation of neuron apoptotic process GO:0043524 IMP
    establishment of protein localization GO:0045184 ISO
    cell division GO:0051301 IMP
    regulation of cell maturation GO:1903429 IMP
    regulation of G1/S transition of mitotic cell cycle GO:2000045 ISO
    regulation of G1/S transition of mitotic cell cycle GO:2000045 ISS
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    kinesin complex GO:0005871 IBA
    microtubule GO:0005874 IBA
    microtubule GO:0005874 ISO
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 ISS
    midbody GO:0030496 ISO
    midbody GO:0030496 ISS
    spindle midzone GO:0051233 ISO
    spindle midzone GO:0051233 ISS
    Flemming body GO:0090543 IEA
    Flemming body GO:0090543 ISO
 Experiment description of studies that identified Kif14 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Kif14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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