Gene description for Gatc
Gene name glutamyl-tRNA(Gln) amidotransferase, subunit C
Gene symbol Gatc
Other names/aliases 2010003O18Rik
Species Mus musculus
 Database cross references - Gatc
ExoCarta ExoCarta_384281
Entrez Gene 384281
UniProt Q8CBY0  
 Gatc identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Gatc
Molecular Function
    ligase activity GO:0016874 IEA
    nucleotide binding GO:0000166 IEA
    glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity GO:0050567 ISO
    cobyrinate a,c-diamide synthase activity GO:0043775 IEA
    ATP binding GO:0005524 IEA
Biological Process
    regulation of translational fidelity GO:0006450 IEA
    glutaminyl-tRNAGln biosynthesis via transamidation GO:0070681 ISO
    translation GO:0006412 IEA
    mitochondrial translation GO:0032543 ISO
Subcellular Localization
    mitochondrion GO:0005739 ISO
    glutamyl-tRNA(Gln) amidotransferase complex GO:0030956 ISO
 Experiment description of studies that identified Gatc in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Gatc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gatc is involved
No pathways found





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