Gene description for mthl2
Gene name methuselah-like 2
Gene symbol mthl2
Other names/aliases CG17795
DmelCG17795
Mth-2
anon-WO0170980.28
anon-WO0170980.29
Species Drosophila melanogaster
 Database cross references - mthl2
ExoCarta ExoCarta_38636
Entrez Gene 38636
UniProt Q9VRN2  
 mthl2 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for mthl2
Molecular Function
    G-protein coupled receptor activity GO:0004930 ISS
Biological Process
    determination of adult lifespan GO:0008340 ISS
    G-protein coupled receptor signaling pathway GO:0007186 ISS
    response to starvation GO:0042594 ISS
Subcellular Localization
    integral component of membrane GO:0016021 ISS
 Experiment description of studies that identified mthl2 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for mthl2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which mthl2 is involved
No pathways found





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