Gene description for Eid2
Gene name EP300 interacting inhibitor of differentiation 2
Gene symbol Eid2
Other names/aliases Cri2
EID-2
Species Mus musculus
 Database cross references - Eid2
ExoCarta ExoCarta_386655
Vesiclepedia VP_386655
Entrez Gene 386655
UniProt Q6X7S9  
 Eid2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Eid2
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    SMAD binding GO:0046332 ISO
    SMAD binding GO:0046332 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    transforming growth factor beta receptor complex assembly GO:0007181 ISO
    transforming growth factor beta receptor complex assembly GO:0007181 ISS
    muscle organ development GO:0007517 IEA
    cell differentiation GO:0030154 IEA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISS
    regulation of cell population proliferation GO:0042127 ISO
    regulation of cell population proliferation GO:0042127 ISS
    negative regulation of DNA-templated transcription GO:0045892 IBA
    negative regulation of SMAD protein signal transduction GO:0060392 ISO
    negative regulation of SMAD protein signal transduction GO:0060392 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Eid2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Eid2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Eid2 is involved
No pathways found





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