Gene description for SP5
Gene name Sp5 transcription factor
Gene symbol SP5
Other names/aliases -
Species Homo sapiens
 Database cross references - SP5
ExoCarta ExoCarta_389058
Vesiclepedia VP_389058
Entrez Gene 389058
HGNC 14529
MIM 609391
UniProt Q6BEB4  
 SP5 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SP5
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    post-anal tail morphogenesis GO:0036342 IEA
    bone morphogenesis GO:0060349 IEA
    cellular response to organic cyclic compound GO:0071407 IEA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified SP5 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SP5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NKX3-1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SP5 is involved
No pathways found





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