Gene description for LFNG
Gene name LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Gene symbol LFNG
Other names/aliases SCDO3
Species Homo sapiens
 Database cross references - LFNG
ExoCarta ExoCarta_3955
Entrez Gene 3955
HGNC 6560
MIM 602576
UniProt Q8NES3  
 LFNG identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
 Gene ontology annotations for LFNG
Molecular Function
    molecular_function GO:0003674 ND
    O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity GO:0033829 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    metabolic process GO:0008152 ISS
    ovarian follicle development GO:0001541 IEA
    female meiotic division GO:0007143 IEA
    positive regulation of protein binding GO:0032092 IEA
    organ morphogenesis GO:0009887 NAS
    compartment pattern specification GO:0007386 IEA
    Notch signaling pathway GO:0007219 TAS
    positive regulation of Notch signaling pathway GO:0045747 IEA
    regulation of somitogenesis GO:0014807 IMP
    somitogenesis GO:0001756 IEA
    regulation of Notch signaling pathway GO:0008593 ISS
Subcellular Localization
    integral component of Golgi membrane GO:0030173 IEA
    extracellular vesicle GO:1903561 IDA
    extracellular region GO:0005576 NAS
 Experiment description of studies that identified LFNG in exosomes
1
Experiment ID 21
ISEV standards
✔
EM|IEM
EV Biophysical techniques
✔
Alix|TSG101|HSP70
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for LFNG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NOTCH1 4851
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which LFNG is involved
PathwayEvidenceSource
Pre-NOTCH Processing in Golgi TAS Reactome





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