Gene description for Cat
Gene name Catalase
Gene symbol Cat
Other names/aliases CAT
CATA
CG6871
CT21282
CatA
DMCATHPO
DROCATHPO
DmelCG6871
U00145
bs36h11.y1
cat
Species Drosophila melanogaster
 Database cross references - Cat
ExoCarta ExoCarta_40048
Vesiclepedia VP_40048
Entrez Gene 40048
UniProt P17336  
 Cat identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Cat
Molecular Function
    catalase activity GO:0004096 IDA
    catalase activity GO:0004096 IGI
    catalase activity GO:0004096 IMP
    catalase activity GO:0004096 ISS
Biological Process
    heart morphogenesis GO:0003007 IMP
    determination of adult lifespan GO:0008340 TAS
    response to endoplasmic reticulum stress GO:0034976 IMP
    regulation of hemocyte proliferation GO:0035206 IMP
    intestinal stem cell homeostasis GO:0036335 IMP
    paracrine signaling GO:0038001 IMP
    response to hydrogen peroxide GO:0042542 IMP
    hydrogen peroxide catabolic process GO:0042744 IGI
    regulation of synaptic plasticity GO:0048167 IMP
    reactive oxygen species metabolic process GO:0072593 IMP
Subcellular Localization
    mitochondrion GO:0005739 IDA
    peroxisome GO:0005777 ISM
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Cat in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cat
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PGRP-LC  
Affinity Capture-MS Drosophila melanogaster
2 cry  
Proximity Label-MS Drosophila melanogaster
3 Tak1  
Affinity Capture-MS Drosophila melanogaster
4 key  
Affinity Capture-MS Drosophila melanogaster
5 CG5009  
Two-hybrid Drosophila melanogaster
6 E2f2  
Two-hybrid Drosophila melanogaster
7 CG31343  
Affinity Capture-MS Drosophila melanogaster
8 CG16826  
Affinity Capture-MS Drosophila melanogaster
9 Tab2  
Affinity Capture-MS Drosophila melanogaster
10 Yp2  
Affinity Capture-MS Drosophila melanogaster
11 CG5380  
Two-hybrid Drosophila melanogaster
12 imd  
Affinity Capture-MS Drosophila melanogaster
13 CG11581  
Two-hybrid Drosophila melanogaster
14 Pink1  
Phenotypic Suppression Drosophila melanogaster
15 Fadd  
Affinity Capture-MS Drosophila melanogaster
16 Rel  
Affinity Capture-MS Drosophila melanogaster
17 PGRP-LE  
Affinity Capture-MS Drosophila melanogaster
18 Iap2  
Affinity Capture-MS Drosophila melanogaster
19 ird5  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here