Gene description for Cat
Gene name Catalase
Gene symbol Cat
Other names/aliases CAT
CATA
CG6871
CT21282
CatA
DMCATHPO
DROCATHPO
DmelCG6871
U00145
bs36h11.y1
cat
Species Drosophila melanogaster
 Database cross references - Cat
ExoCarta ExoCarta_40048
Entrez Gene 40048
UniProt P17336  
 Cat identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Cat
Molecular Function
    heme binding GO:0020037 NAS
    catalase activity GO:0004096 NAS
    antioxidant activity GO:0016209 NAS
Biological Process
    regulation of hemocyte proliferation GO:0035206 IMP
    oxidation-reduction process GO:0055114 IEA
    determination of adult lifespan GO:0008340 TAS
    heart morphogenesis GO:0003007 IMP
    paracrine signaling GO:0038001 IMP
    reactive oxygen species metabolic process GO:0072593 IMP
    aging GO:0007568 TAS
    response to ethanol GO:0045471 IMP
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 NAS
    response to hydrogen peroxide GO:0042542 TAS
    response to oxidative stress GO:0006979 NAS
Subcellular Localization
    peroxisome GO:0005777 NAS
    plasma membrane GO:0005886 NAS
 Experiment description of studies that identified Cat in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Cat
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cat is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome
Purine catabolism IEA Reactome





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