Gene description for AGO2
Gene name argonaute RISC catalytic component 2
Gene symbol AGO2
Other names/aliases EIF2C2
Species Bos taurus
 Database cross references - AGO2
ExoCarta ExoCarta_404130
Entrez Gene 404130
UniProt Q6QME8  
 AGO2 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for AGO2
Molecular Function
    endoribonuclease activity, cleaving siRNA-paired mRNA GO:0070551 ISS
    siRNA binding GO:0035197 ISS
    miRNA binding GO:0035198 IEA
    RNA 7-methylguanosine cap binding GO:0000340 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 ISS
    negative regulation of translational initiation GO:0045947 ISS
    regulation of transcription, DNA-templated GO:0006355 IEA
    mRNA cleavage involved in gene silencing by miRNA GO:0035279 ISS
    negative regulation of translation involved in gene silencing by miRNA GO:0035278 ISS
    pre-miRNA processing GO:0031054 ISS
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    polysome GO:0005844 ISS
    nucleus GO:0005634 IEA
    RISC-loading complex GO:0070578 ISS
    micro-ribonucleoprotein complex GO:0035068 ISS
    RISC complex GO:0016442 IEA
    ribonucleoprotein complex GO:0030529 ISS
    cytoplasmic mRNA processing body GO:0000932 IEA
    mRNA cap binding complex GO:0005845 ISS
 Experiment description of studies that identified AGO2 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AGO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AGO2 is involved
No pathways found





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