Gene description for H2afy2
Gene name H2A histone family, member Y2
Gene symbol H2afy2
Other names/aliases macroH2A2
Species Mus musculus
 Database cross references - H2afy2
ExoCarta ExoCarta_404634
Entrez Gene 404634
UniProt Q8CCK0  
 H2afy2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for H2afy2
Molecular Function
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 ISO
    chromatin DNA binding GO:0031490 ISO
    DNA binding GO:0003677 IEA
    protein heterodimerization activity GO:0046982 IEA
    transcription regulatory region DNA binding GO:0044212 ISO
Biological Process
    positive regulation of keratinocyte differentiation GO:0045618 ISO
    negative regulation of gene expression, epigenetic GO:0045814 ISO
    establishment of protein localization to chromatin GO:0071169 ISO
    chromatin modification GO:0016568 IEA
    brain development GO:0007420 ISO
    negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter GO:1901837 ISO
    nucleosome assembly GO:0006334 IEA
    dosage compensation GO:0007549 ISA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
Subcellular Localization
    chromosome GO:0005694 IEA
    chromatin GO:0000785 ISO
    nucleoplasm GO:0005654 ISO
    Barr body GO:0001740 ISA
    extracellular exosome GO:0070062 ISO
    ESC/E(Z) complex GO:0035098 ISO
    nucleosome GO:0000786 IEA
    nuclear chromatin GO:0000790 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified H2afy2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for H2afy2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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