Gene description for tacc
Gene name transforming acidic coiled-coil protein
Gene symbol tacc
Other names/aliases CG9765
D-TACC
D-tacc
DTACC
DmelCG9765
TACC
TACCdm
acc
d-tacc
dTACC
dtacc
Species Drosophila melanogaster
 Database cross references - tacc
ExoCarta ExoCarta_40589
Vesiclepedia VP_40589
Entrez Gene 40589
 tacc identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for tacc
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 TAS
Biological Process
    microtubule cytoskeleton organization GO:0000226 IMP
    mitotic cell cycle GO:0000278 IMP
    negative regulation of microtubule depolymerization GO:0007026 TAS
    mitotic spindle organization GO:0007052 TAS
    nuclear migration GO:0007097 IMP
    female meiotic nuclear division GO:0007143 TAS
    pole cell formation GO:0007279 IMP
    pronuclear fusion GO:0007344 TAS
    protein localization GO:0008104 IMP
    pronuclear migration GO:0035046 IMP
Subcellular Localization
    astral microtubule GO:0000235 IDA
    astral microtubule GO:0000235 TAS
    spindle pole GO:0000922 IDA
    centrosome GO:0005813 IDA
    centrosome GO:0005813 IDA
    spindle microtubule GO:0005876 IDA
 Experiment description of studies that identified tacc in sEVs
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for tacc
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Hira  
Affinity Capture-MS Drosophila melanogaster
2 Dredd  
Affinity Capture-MS Drosophila melanogaster
3 Tak1  
Affinity Capture-MS Drosophila melanogaster
4 key  
Affinity Capture-MS Drosophila melanogaster
5 TBPH  
Two-hybrid Drosophila melanogaster
6 CG14540  
Two-hybrid Drosophila melanogaster
7 Tab2  
Affinity Capture-MS Drosophila melanogaster
8 CG13423  
Two-hybrid Drosophila melanogaster
9 msps  
Affinity Capture-Western Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
Affinity Capture-Western Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
10 Fadd  
Affinity Capture-MS Drosophila melanogaster
11 Rel  
Affinity Capture-MS Drosophila melanogaster
12 PGRP-LE  
Affinity Capture-MS Drosophila melanogaster
13 Iap2  
Affinity Capture-MS Drosophila melanogaster
14 CG10164  
Affinity Capture-MS Drosophila melanogaster
15 ird5  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which tacc is involved
No pathways found





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