Gene description for KRIT1
Gene name KRIT1, ankyrin repeat containing
Gene symbol KRIT1
Other names/aliases CCM1
Species Bos taurus
 Database cross references - KRIT1
ExoCarta ExoCarta_407996
Entrez Gene 407996
UniProt Q6TNJ1  
 KRIT1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for KRIT1
Molecular Function
    microtubule binding GO:0008017 ISS
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISS
    protein complex binding GO:0032403 ISS
Biological Process
    negative regulation of endothelial cell proliferation GO:0001937 ISS
    angiogenesis GO:0001525 IEA
    regulation of establishment of cell polarity GO:2000114 ISS
    negative regulation of angiogenesis GO:0016525 ISS
    negative regulation of endothelial cell migration GO:0010596 ISS
    negative regulation of endothelial cell apoptotic process GO:2000352 ISS
Subcellular Localization
    microtubule GO:0005874 ISS
    cell-cell junction GO:0005911 ISS
    plasma membrane GO:0005886 ISS
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified KRIT1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KRIT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which KRIT1 is involved
No pathways found





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