Gene description for APOC3
Gene name apolipoprotein C-III
Gene symbol APOC3
Other names/aliases -
Species Bos taurus
 Database cross references - APOC3
ExoCarta ExoCarta_408009
Entrez Gene 408009
UniProt P19035  
 APOC3 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for APOC3
Molecular Function
    lipase inhibitor activity GO:0055102 IEA
    phospholipid binding GO:0005543 IEA
    high-density lipoprotein particle receptor binding GO:0070653 IEA
Biological Process
    high-density lipoprotein particle remodeling GO:0034375 IEA
    negative regulation of triglyceride catabolic process GO:0010897 IEA
    triglyceride catabolic process GO:0019433 IEA
    negative regulation of fatty acid biosynthetic process GO:0045717 IEA
    negative regulation of high-density lipoprotein particle clearance GO:0010987 IEA
    chylomicron remnant clearance GO:0034382 IEA
    triglyceride homeostasis GO:0070328 IEA
    negative regulation of very-low-density lipoprotein particle clearance GO:0010916 IEA
    phospholipid efflux GO:0033700 IEA
    negative regulation of receptor-mediated endocytosis GO:0048261 IEA
    regulation of Cdc42 protein signal transduction GO:0032489 IEA
    cholesterol homeostasis GO:0042632 IEA
    cholesterol efflux GO:0033344 IEA
    cholesterol metabolic process GO:0008203 IEA
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    negative regulation of cholesterol import GO:0060621 IEA
    negative regulation of lipoprotein lipase activity GO:0051005 IEA
    triglyceride mobilization GO:0006642 IEA
    lipoprotein metabolic process GO:0042157 IEA
    negative regulation of low-density lipoprotein particle clearance GO:0010989 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    chylomicron GO:0042627 IEA
    very-low-density lipoprotein particle GO:0034361 IEA
    spherical high-density lipoprotein particle GO:0034366 IEA
    intermediate-density lipoprotein particle GO:0034363 IEA
 Experiment description of studies that identified APOC3 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for APOC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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