Gene description for AdSS
Gene name Adenylosuccinate Synthetase
Gene symbol AdSS
Other names/aliases BcDNA:LD32788
CG17273
DmelCG17273
PURA_DROME
Species Drosophila melanogaster
 Database cross references - AdSS
ExoCarta ExoCarta_42466
Entrez Gene 42466
UniProt Q9Y0Y2  
 AdSS identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for AdSS
Molecular Function
    adenylosuccinate synthase activity GO:0004019 NAS
    GTP binding GO:0005525 IEA
Biological Process
    purine nucleotide biosynthetic process GO:0006164 NAS
    neurogenesis GO:0022008 IMP
 Experiment description of studies that identified AdSS in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AdSS
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AdSS is involved
PathwayEvidenceSource
Purine ribonucleoside monophosphate biosynthesis IEA Reactome





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