Gene description for MGP
Gene name matrix Gla protein
Gene symbol MGP
Other names/aliases GIG36
MGLAP
NTI
Species Homo sapiens
 Database cross references - MGP
ExoCarta ExoCarta_4256
Entrez Gene 4256
HGNC 7060
MIM 154870
UniProt P08493  
 MGP identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Saliva 19199708    
 Gene ontology annotations for MGP
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of bone GO:0008147 TAS
    calcium ion binding GO:0005509 IEA
    extracellular matrix structural constituent GO:0005201 TAS
Biological Process
    cell differentiation GO:0030154 IEA
    regulation of bone mineralization GO:0030500 IEA
    cartilage condensation GO:0001502 TAS
    ossification GO:0001503 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    proteinaceous extracellular matrix GO:0005578 TAS
    extracellular matrix GO:0031012 IDA
 Experiment description of studies that identified MGP in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for MGP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BMP2  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which MGP is involved
No pathways found





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