Gene description for MGP |
Gene name |
matrix Gla protein |
Gene symbol |
MGP |
Other names/aliases |
GIG36 MGLAP NTI |
Species |
Homo sapiens |
Database cross references - MGP |
ExoCarta |
ExoCarta_4256 |
Entrez Gene |
4256 |
HGNC |
7060 |
MIM |
154870 |
UniProt |
P08493
|
MGP identified in exosomes derived from the following tissue/cell type |
Hepatocytes
|
26054723
|
Saliva
|
19199708
|
Gene ontology annotations for MGP |
|
Experiment description of studies that identified MGP in exosomes |
1 |
Experiment ID |
237 |
ISEV standards |
✔
EM
|
EV Biophysical techniques |
✔
TSG101|Alix|HSC70|GAPDH
|
EV Cytosolic markers |
✘
|
EV Membrane markers |
✔
HSP90B1
|
EV Negative markers |
✔
qNano
|
EV Particle analysis
|
|
Identified molecule |
mRNA
|
Identification method |
RNA Sequencing
|
PubMed ID |
26054723
|
Organism |
Homo sapiens |
Experiment description |
Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs |
Authors |
He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N |
Journal name |
Carcinogenesis
|
Publication year |
2015 |
Sample |
Hepatocytes |
Sample name |
MIHA |
Isolation/purification methods |
Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient |
Flotation density |
1.13-1.19 g/mL
|
Molecules identified in the study |
Protein RNA |
Methods used in the study |
Western blotting Mass spectrometry RNA Sequencing |
|
|
2 |
Experiment ID |
66 |
ISEV standards |
✔
IEM
|
EV Biophysical techniques |
✔
TSG101|Alix
|
EV Cytosolic markers |
✔
CD63|CD81
|
EV Membrane markers |
✘
|
EV Negative markers |
✘
|
EV Particle analysis
|
|
Identified molecule |
protein
|
Identification method |
Mass spectrometry
|
PubMed ID |
19199708
|
Organism |
Homo sapiens |
Experiment description |
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). |
Authors |
Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR |
Journal name |
JPR
|
Publication year |
2009 |
Sample |
Saliva |
Sample name |
Saliva |
Isolation/purification methods |
Differential centrifugation |
Flotation density |
-
|
Molecules identified in the study |
Protein |
Methods used in the study |
Mass spectrometry [LTQ] Western blotting Immunoelectron Microscopy |
|
|
Protein-protein interactions for MGP |
|
Pathways in which MGP is involved |
No pathways found
|
|
|