Gene description for Syx1A
Gene name Syntaxin 1A
Gene symbol Syx1A
Other names/aliases CG10716
CG18615
CG31136
CG5448
CT30033
Dm Syx1
DmSyx1A
DmelCG31136
SYX
SYX 1A
SYX1A
Syt1A
Syx
Syx-1A
Syx1
Syx1a
SyxA
anon-EST:Gibbs4
anon-WO02059370.54
dSyx1
dsyn-1A
l(3)06737
synt
syt-1A
syx
syx-1
syx-1A
syx1
syx1A
Species Drosophila melanogaster
 Database cross references - Syx1A
ExoCarta ExoCarta_42854
Vesiclepedia VP_42854
Entrez Gene 42854
UniProt Q24547  
 Syx1A identified in exosomes derived from the following tissue/cell type
Embryonic cells 31666321    
Hemolymph 31666321    
Hemolymph 31666321    
 Gene ontology annotations for Syx1A
Molecular Function
    SNARE binding GO:0000149 IPI
    SNAP receptor activity GO:0005484 IDA
    SNAP receptor activity GO:0005484 ISS
    SNAP receptor activity GO:0005484 NAS
    protein binding GO:0005515 IPI
Biological Process
    mitotic cytokinesis GO:0000281 IMP
    vesicle fusion GO:0006906 IDA
    neurotransmitter secretion GO:0007269 IMP
    neurotransmitter secretion GO:0007269 NAS
    neuromuscular synaptic transmission GO:0007274 IEP
    regulation of pole plasm oskar mRNA localization GO:0007317 IMP
    cellularization GO:0007349 TAS
    haltere development GO:0007482 IGI
    synaptic vesicle docking GO:0016081 ISS
    vesicle-mediated transport GO:0016192 NAS
    synaptic vesicle fusion to presynaptic active zone membrane GO:0031629 IDA
    synaptic vesicle fusion to presynaptic active zone membrane GO:0031629 IMP
    secretion of lysosomal enzymes GO:0033299 IMP
    liquid clearance, open tracheal system GO:0035002 IMP
    membrane fusion GO:0061025 IMP
    exosomal secretion GO:1990182 IMP
Subcellular Localization
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 NAS
    synaptic vesicle GO:0008021 IDA
    SNARE complex GO:0031201 IDA
    terminal bouton GO:0043195 IDA
 Experiment description of studies that identified Syx1A in exosomes
1
Experiment ID 1227
MISEV standards
✘ Biophysical techniques
✔
TSG101|Rab11
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 31666321    
Organism Drosophila melanogaster
Experiment description Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and response to hypoxia
Authors "Tsai YW, Sung HH, Li JC, Yeh CY, Chen PY, Cheng YJ, Chen CH, Tsai YC, Chien CT. "
Journal name Proc Natl Acad Sci U S A
Publication year 2019
Sample Embryonic cells
Sample name S2
Isolation/purification methods Differential centrifugation
ExoQuick Kit
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study RT-PCR
Western blotting
2
Experiment ID 1228
MISEV standards
✘ Biophysical techniques
✔
TSG101|Rab11
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 31666321    
Organism Drosophila melanogaster
Experiment description Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and response to hypoxia
Authors "Tsai YW, Sung HH, Li JC, Yeh CY, Chen PY, Cheng YJ, Chen CH, Tsai YC, Chien CT. "
Journal name Proc Natl Acad Sci U S A
Publication year 2019
Sample Hemolymph
Sample name Circulating hemolymph
Isolation/purification methods Differential centrifugation
ExoQuick Kit
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study RT-PCR
Western blotting
3
Experiment ID 1229
MISEV standards
✘ Biophysical techniques
✔
TSG101|Rab11
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 31666321    
Organism Drosophila melanogaster
Experiment description Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and response to hypoxia
Authors "Tsai YW, Sung HH, Li JC, Yeh CY, Chen PY, Cheng YJ, Chen CH, Tsai YC, Chien CT. "
Journal name Proc Natl Acad Sci U S A
Publication year 2019
Sample Hemolymph
Sample name Circulating hemolymph
Isolation/purification methods Differential centrifugation
ExoQuick Kit
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for Syx1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Syb  
Two-hybrid Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
2 Snap25  
Affinity Capture-MS Drosophila melanogaster
3 Syx5  
Affinity Capture-MS Drosophila melanogaster
4 gammaSnap2  
Affinity Capture-MS Drosophila melanogaster
5 Membrin  
Affinity Capture-MS Drosophila melanogaster
6 Syx16  
Affinity Capture-MS Drosophila melanogaster
7 CG34404  
Two-hybrid Drosophila melanogaster
8 Past1  
Affinity Capture-MS Drosophila melanogaster
9 CG15124  
Two-hybrid Drosophila melanogaster
10 Gos28  
Affinity Capture-MS Drosophila melanogaster
11 Snap24 41193
Affinity Capture-MS Drosophila melanogaster
12 gammaSnap1  
Affinity Capture-MS Drosophila melanogaster
13 Use1  
Affinity Capture-MS Drosophila melanogaster
14 Syx18  
Affinity Capture-MS Drosophila melanogaster
15 AttD  
Affinity Capture-MS Drosophila melanogaster
16 Slh  
Affinity Capture-MS Drosophila melanogaster
17 Vamp7  
Two-hybrid Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
18 CG13476  
Two-hybrid Drosophila melanogaster
19 Ykt6  
Affinity Capture-MS Drosophila melanogaster
20 Snap29  
Two-hybrid Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
21 Vti1  
Affinity Capture-MS Drosophila melanogaster
22 CG7110  
Two-hybrid Drosophila melanogaster
23 Sec22  
Affinity Capture-MS Drosophila melanogaster
24 Syx8  
Affinity Capture-MS Drosophila melanogaster
25 alphaSnap  
Two-hybrid Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
26 Syx13  
Affinity Capture-MS Drosophila melanogaster
27 14-3-3zeta  
Two-hybrid Drosophila melanogaster
28 Syx7  
Affinity Capture-MS Drosophila melanogaster
29 CG2023  
Affinity Capture-MS Drosophila melanogaster
30 Nsf2  
Affinity Capture-MS Drosophila melanogaster
31 CG2199  
Two-hybrid Drosophila melanogaster
32 nSyb  
Affinity Capture-MS Drosophila melanogaster
33 Rme-8 35939
Affinity Capture-MS Drosophila melanogaster
34 Bet1  
Affinity Capture-MS Drosophila melanogaster
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