Gene description for MMP11
Gene name matrix metallopeptidase 11
Gene symbol MMP11
Other names/aliases SL-3
ST3
STMY3
Species Homo sapiens
 Database cross references - MMP11
ExoCarta ExoCarta_4320
Vesiclepedia VP_4320
Entrez Gene 4320
HGNC 7157
MIM 185261
UniProt P24347  
 MMP11 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MMP11
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 TAS
    serine-type endopeptidase activity GO:0004252 TAS
    zinc ion binding GO:0008270 IEA
Biological Process
    proteolysis GO:0006508 IEA
    extracellular matrix disassembly GO:0022617 TAS
    extracellular matrix organization GO:0030198 IBA
    collagen fibril organization GO:0030199 IEA
    collagen catabolic process GO:0030574 IBA
    collagen catabolic process GO:0030574 TAS
    negative regulation of fat cell differentiation GO:0045599 IEA
    basement membrane organization GO:0071711 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    Golgi lumen GO:0005796 TAS
    extracellular matrix GO:0031012 IDA
 Experiment description of studies that identified MMP11 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MMP11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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