Gene description for ALiX
Gene name ALG-2 interacting protein X
Gene symbol ALiX
Other names/aliases AIP1
ALIX
Aip1
Alix
CG12876
DAIP1
DmelCG12876
Snf7
Species Drosophila melanogaster
 Database cross references - ALiX
ExoCarta ExoCarta_43330
Vesiclepedia VP_43330
Entrez Gene 43330
 ALiX identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for ALiX
Biological Process
    mitotic cytokinesis GO:0000281 IMP
    actin filament polymerization GO:0030041 IMP
    positive regulation of JNK cascade GO:0046330 IDA
    female germ-line stem cell asymmetric division GO:0048132 IMP
    male germ-line stem cell asymmetric division GO:0048133 IMP
    exosomal secretion GO:1990182 IMP
Subcellular Localization
    centrosome GO:0005813 IDA
    midbody GO:0030496 IDA
    intercellular bridge GO:0045171 IDA
    contractile ring GO:0070938 IDA
 Experiment description of studies that identified ALiX in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ALiX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 mRpS7  
Two-hybrid Drosophila melanogaster
2 CG44098  
Two-hybrid Drosophila melanogaster
3 CG30263  
Two-hybrid Drosophila melanogaster
4 grk  
Two-hybrid Drosophila melanogaster
5 brp  
Two-hybrid Drosophila melanogaster
6 Lmpt  
Two-hybrid Drosophila melanogaster
7 CG34354  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml
 Pathways in which ALiX is involved
No pathways found





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