Gene description for Pcd
Gene name pterin-4a-carbinolamine dehydratase
Gene symbol Pcd
Other names/aliases BcDNA:LP07248
CG1963
DmelCG1963
PCD
Species Drosophila melanogaster
 Database cross references - Pcd
ExoCarta ExoCarta_43499
Entrez Gene 43499
UniProt O76454  
 Pcd identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Pcd
Molecular Function
    4-alpha-hydroxytetrahydrobiopterin dehydratase activity GO:0008124 NAS
Biological Process
    tetrahydrobiopterin biosynthetic process GO:0006729 ISS
 Experiment description of studies that identified Pcd in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pcd
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pcd is involved
PathwayEvidenceSource
Phenylalanine and tyrosine catabolism IEA Reactome





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