Gene description for MUC6
Gene name mucin 6, oligomeric mucus/gel-forming
Gene symbol MUC6
Other names/aliases MUC-6
Species Homo sapiens
 Database cross references - MUC6
ExoCarta ExoCarta_4588
Vesiclepedia VP_4588
Entrez Gene 4588
HGNC 7517
MIM 158374
UniProt Q6W4X9  
 MUC6 identified in exosomes derived from the following tissue/cell type
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for MUC6
Molecular Function
    extracellular matrix structural constituent GO:0005201 NAS
Biological Process
    post-translational protein modification GO:0043687 TAS
    cellular protein metabolic process GO:0044267 TAS
    maintenance of gastrointestinal epithelium GO:0030277 NAS
    protein O-linked glycosylation GO:0006493 TAS
    O-glycan processing GO:0016266 TAS
Subcellular Localization
    Golgi lumen GO:0005796 TAS
    extracellular region GO:0005576 IEA
 Experiment description of studies that identified MUC6 in exosomes
1
Experiment ID 196
MISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 197
MISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MUC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MUC6 is involved
PathwayEvidenceSource
O-linked glycosylation of mucins TAS Reactome
Termination of O-glycan biosynthesis TAS Reactome





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