Gene description for CEACAM6
Gene name carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
Gene symbol CEACAM6
Other names/aliases CD66c
CEAL
NCA
Species Homo sapiens
 Database cross references - CEACAM6
ExoCarta ExoCarta_4680
Vesiclepedia VP_4680
Entrez Gene 4680
HGNC 1818
MIM 163980
UniProt P40199  
 CEACAM6 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for CEACAM6
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    leukocyte migration GO:0050900 TAS
    blood coagulation GO:0007596 TAS
    cell-cell signaling GO:0007267 TAS
    signal transduction GO:0007165 TAS
Subcellular Localization
    anchored component of membrane GO:0031225 IEA
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified CEACAM6 in exosomes
1
Experiment ID 1203
MISEV standards
✔
EM
EV Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for CEACAM6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CEACAM6 is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome
Fibronectin matrix formation TAS Reactome





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