Gene description for FKBP59
Gene name FK506-binding protein FKBP59
Gene symbol FKBP59
Other names/aliases CG4535
DmelCG4535
FKBP59-bp1
anon-WO0118547.161
dFKBP59
l(2)k00424
l(2)k09010
Species Drosophila melanogaster
 Database cross references - FKBP59
ExoCarta ExoCarta_47762
Vesiclepedia VP_47762
Entrez Gene 47762
UniProt Q9VL78  
 FKBP59 identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for FKBP59
Molecular Function
    protein binding GO:0005515 IPI
    FK506 binding GO:0005528 ISS
Biological Process
    detection of light stimulus involved in visual perception GO:0050908 IPI
    regulation of calcium ion transport GO:0051924 IDA
Subcellular Localization
    inaD signaling complex GO:0016027 IPI
 Experiment description of studies that identified FKBP59 in sEVs
1
Experiment ID 202
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG10|RAB35|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FKBP59
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTPsyn  
Proximity Label-MS Drosophila melanogaster
2 CG30496  
Affinity Capture-MS Drosophila melanogaster
3 cry  
Proximity Label-MS Drosophila melanogaster
Affinity Capture-Western Drosophila melanogaster
4 AGO1  
Two-hybrid Drosophila melanogaster
5 Sh3beta 38820
Affinity Capture-MS Drosophila melanogaster
6 dUTPase  
Affinity Capture-MS Drosophila melanogaster
7 Prx2540-2 36098
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml



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