Gene description for NPR2
Gene name natriuretic peptide receptor 2
Gene symbol NPR2
Other names/aliases AMDM
ANPRB
ANPb
ECDM
GUC2B
GUCY2B
NPRB
NPRBi
Species Homo sapiens
 Database cross references - NPR2
ExoCarta ExoCarta_4882
Vesiclepedia VP_4882
Entrez Gene 4882
HGNC 7944
MIM 108961
UniProt P20594  
 NPR2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NPR2
Molecular Function
    guanylate cyclase activity GO:0004383 IBA
    guanylate cyclase activity GO:0004383 IDA
    guanylate cyclase activity GO:0004383 IMP
    protein kinase activity GO:0004672 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    GTP binding GO:0005525 IEA
    natriuretic peptide receptor activity GO:0016941 IBA
    natriuretic peptide receptor activity GO:0016941 IDA
    natriuretic peptide receptor activity GO:0016941 IMP
    peptide hormone binding GO:0017046 IBA
    peptide hormone binding GO:0017046 IPI
    hormone binding GO:0042562 IPI
    identical protein binding GO:0042802 IEA
Biological Process
    MAPK cascade GO:0000165 IEA
    cumulus cell differentiation GO:0001549 IEA
    vasculogenesis GO:0001570 IEA
    lymph vessel development GO:0001945 IEA
    endochondral ossification GO:0001958 IEA
    startle response GO:0001964 IEA
    blood vessel remodeling GO:0001974 IEA
    chondrocyte differentiation GO:0002062 IEA
    growth plate cartilage development GO:0003417 IEA
    cGMP biosynthetic process GO:0006182 IBA
    cGMP biosynthetic process GO:0006182 IDA
    vacuole organization GO:0007033 IEA
    receptor guanylyl cyclase signaling pathway GO:0007168 IBA
    receptor guanylyl cyclase signaling pathway GO:0007168 IDA
    receptor guanylyl cyclase signaling pathway GO:0007168 IMP
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    chemical synaptic transmission GO:0007268 IEA
    spermatogenesis GO:0007283 IEA
    sensory perception of sound GO:0007605 IEA
    regulation of blood pressure GO:0008217 TAS
    neuronal action potential GO:0019228 IEA
    vestibulocochlear nerve maturation GO:0021647 IEA
    female genitalia development GO:0030540 IEA
    response to luteinizing hormone GO:0034699 IEA
    limb morphogenesis GO:0035108 IEA
    genitalia morphogenesis GO:0035112 IEA
    multicellular organism growth GO:0035264 IEA
    gastric emptying GO:0035483 IEA
    chondrocyte proliferation GO:0035988 IEA
    post-anal tail morphogenesis GO:0036342 IEA
    digestive tract morphogenesis GO:0048546 IEA
    collateral sprouting GO:0048668 IEA
    smooth muscle tissue development GO:0048745 IEA
    white fat cell differentiation GO:0050872 IEA
    chromosome organization GO:0051276 IEA
    neuron apoptotic process GO:0051402 IEA
    negative regulation of meiotic cell cycle GO:0051447 IEA
    axonogenesis involved in innervation GO:0060385 IEA
    activation of meiosis involved in egg activation GO:0060466 IEA
    vascular wound healing GO:0061042 IEA
    c-di-GMP signaling GO:0061939 IEA
    cellular response to cGMP GO:0071321 IEA
    response to fibroblast growth factor GO:0071774 IEA
    cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 IEP
    execution phase of apoptosis GO:0097194 IEA
    negative regulation of oocyte maturation GO:1900194 IEA
    cellular response to peptide GO:1901653 IEA
    response to salt GO:1902074 IEA
    meiotic cell cycle process involved in oocyte maturation GO:1903537 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cilium GO:0005929 IEA
    neuron projection GO:0043005 IEA
    synapse GO:0045202 IEA
 Experiment description of studies that identified NPR2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NPR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MOV10 4343
Affinity Capture-RNA Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 NPPC  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
4 NPPA  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
5 NPPB  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which NPR2 is involved
PathwayEvidenceSource
Cardiac conduction TAS Reactome
Muscle contraction TAS Reactome
Physiological factors TAS Reactome





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