Gene description for NPR3
Gene name natriuretic peptide receptor 3
Gene symbol NPR3
Other names/aliases ANP-C
ANPR-C
ANPRC
C5orf23
GUCY2B
NPR-C
NPRC
Species Homo sapiens
 Database cross references - NPR3
ExoCarta ExoCarta_4883
Entrez Gene 4883
HGNC 7945
MIM 108962
UniProt P17342  
 NPR3 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for NPR3
Molecular Function
    G-protein coupled peptide receptor activity GO:0008528 ISS
    peptide hormone binding GO:0017046 ISS
    natriuretic peptide receptor activity GO:0016941 IDA
    protein homodimerization activity GO:0042803 IEA
    hormone binding GO:0042562 IPI
Biological Process
    negative regulation of adenylate cyclase activity GO:0007194 IEA
    skeletal system development GO:0001501 ISS
    pancreatic juice secretion GO:0030157 IEA
    osteoclast proliferation GO:0002158 ISS
    regulation of osteoblast proliferation GO:0033688 ISS
    negative regulation of smooth muscle cell proliferation GO:0048662 IEA
    regulation of blood pressure GO:0008217 ISS
    phosphatidylinositol-mediated signaling GO:0048015 IEA
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 IEA
    positive regulation of urine volume GO:0035810 ISS
    phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 IEA
    positive regulation of nitric-oxide synthase activity GO:0051000 ISS
Subcellular Localization
    integral component of plasma membrane GO:0005887 IC
    intracellular GO:0005622 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified NPR3 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NPR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NPR3 4883
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
2 NPPA  
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
3 NPPC  
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
4 NPPB  
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which NPR3 is involved
No pathways found





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